The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis
Purpose. To systematically evaluate the associations between oxidative stress status and different types of glaucoma. Design. Systematic review and meta-analysis. Methods. We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between Janu...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/1803619 |
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| _version_ | 1832554560211648512 |
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| author | Binghua Tang Shengjie Li Wenjun Cao Xinghuai Sun |
| author_facet | Binghua Tang Shengjie Li Wenjun Cao Xinghuai Sun |
| author_sort | Binghua Tang |
| collection | DOAJ |
| description | Purpose. To systematically evaluate the associations between oxidative stress status and different types of glaucoma. Design. Systematic review and meta-analysis. Methods. We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between January 1, 1990, and November 30, 2016. A random effects model was used to estimate oxidative stress status along with weighted mean differences and 95% confidence intervals (CIs). A funnel plot analysis and Egger’s test were performed to assess potential publication bias. Main outcome measures. Oxidative stress status was abnormal and different in patients with OAG (open-angle glaucoma) and EXG (exfoliation glaucoma). Results. Blood TAS (total antioxidant status) was lower in the OAG group than in the control group, with a mean difference of 0.580 mmol/L (p<0.0001, 95% CI = −0.668 to −0.492). The aqueous humor SOD (superoxide dismutase), GPX (glutathione peroxidase), and CAT (catalase) levels were higher in the OAG group than in the control group, with mean differences of 17.989 U/mL (p<0.0001, 95% CI = 14.579–21.298), 12.441 U/mL (p<0.0001, 95% CI = 10.423–14.459), and 1.229 fmol/mL (p=0.042, 95% CI = 0.043–2.414), respectively. Blood TAS was lower in the EXG group than in the control group, with a mean difference of 0.262 mmol/L (p<0.0001, 95% CI = −0.393 to −0.132). However, there were no differences in blood TOS and aqueous humor TOS between the EXG group and the control group. Conclusions. This meta-analysis indicates that OAG patients had a lower TAS in the blood and higher levels of SOD, GPX, and CAT in the aqueous humor, while EXG patients only had a decreased TAS in the blood. |
| format | Article |
| id | doaj-art-40c4daa1d17f4f0b93127ea45d069f7f |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-40c4daa1d17f4f0b93127ea45d069f7f2025-02-03T05:51:07ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/18036191803619The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-AnalysisBinghua Tang0Shengjie Li1Wenjun Cao2Xinghuai Sun3Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaPurpose. To systematically evaluate the associations between oxidative stress status and different types of glaucoma. Design. Systematic review and meta-analysis. Methods. We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between January 1, 1990, and November 30, 2016. A random effects model was used to estimate oxidative stress status along with weighted mean differences and 95% confidence intervals (CIs). A funnel plot analysis and Egger’s test were performed to assess potential publication bias. Main outcome measures. Oxidative stress status was abnormal and different in patients with OAG (open-angle glaucoma) and EXG (exfoliation glaucoma). Results. Blood TAS (total antioxidant status) was lower in the OAG group than in the control group, with a mean difference of 0.580 mmol/L (p<0.0001, 95% CI = −0.668 to −0.492). The aqueous humor SOD (superoxide dismutase), GPX (glutathione peroxidase), and CAT (catalase) levels were higher in the OAG group than in the control group, with mean differences of 17.989 U/mL (p<0.0001, 95% CI = 14.579–21.298), 12.441 U/mL (p<0.0001, 95% CI = 10.423–14.459), and 1.229 fmol/mL (p=0.042, 95% CI = 0.043–2.414), respectively. Blood TAS was lower in the EXG group than in the control group, with a mean difference of 0.262 mmol/L (p<0.0001, 95% CI = −0.393 to −0.132). However, there were no differences in blood TOS and aqueous humor TOS between the EXG group and the control group. Conclusions. This meta-analysis indicates that OAG patients had a lower TAS in the blood and higher levels of SOD, GPX, and CAT in the aqueous humor, while EXG patients only had a decreased TAS in the blood.http://dx.doi.org/10.1155/2019/1803619 |
| spellingShingle | Binghua Tang Shengjie Li Wenjun Cao Xinghuai Sun The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis Journal of Ophthalmology |
| title | The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis |
| title_full | The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis |
| title_fullStr | The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis |
| title_short | The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis |
| title_sort | association of oxidative stress status with open angle glaucoma and exfoliation glaucoma a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2019/1803619 |
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