Spontaneous and environment induced genomic alterations in yeast model
While genomic alterations are fundamental to biological evolution, enabling adaptation and diversity, they can also result in detrimental outcomes, such as the development of genetic diseases including cancer. The budding yeast Saccharomyces cerevisiae serves as an exemplary model for investigating...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Insight |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892724000646 |
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| author | Ke-Jing Li Lei Qi Ying-Xuan Zhu Min He Qian Xiang Dao-Qiong Zheng |
| author_facet | Ke-Jing Li Lei Qi Ying-Xuan Zhu Min He Qian Xiang Dao-Qiong Zheng |
| author_sort | Ke-Jing Li |
| collection | DOAJ |
| description | While genomic alterations are fundamental to biological evolution, enabling adaptation and diversity, they can also result in detrimental outcomes, such as the development of genetic diseases including cancer. The budding yeast Saccharomyces cerevisiae serves as an exemplary model for investigating the mechanisms behind various genomic alterations, including point mutations, chromosomal rearrangements, and whole-chromosome aneuploidy. In this review, we highlight the application of genetic screening systems to assess the mutagenic effects of physical and chemical agents efficiently. Additionally, we discuss the utilization of high-throughput sequencing technologies to uncover comprehensive genomic alterations and rare genetic events. We provide a detailed summary of the features of genomic alterations and discuss the genetic mechanisms driving these changes under both spontaneous and stress-induced conditions. Given the high conservation of DNA replication and repair machinery across different organisms, the insights gained from studies on yeast offer valuable perspectives for understanding the delicate balance between genome plasticity and integrity in other species. |
| format | Article |
| id | doaj-art-40b99778f6de42ceb98112ddb35b7124 |
| institution | Kabale University |
| issn | 2772-8927 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj-art-40b99778f6de42ceb98112ddb35b71242025-01-30T05:15:17ZengElsevierCell Insight2772-89272025-02-0141100209Spontaneous and environment induced genomic alterations in yeast modelKe-Jing Li0Lei Qi1Ying-Xuan Zhu2Min He3Qian Xiang4Dao-Qiong Zheng5State Key Laboratory (SKL) of Biobased Transportation Fuel Technology, Ocean College, Zhejiang University, Hangzhou, 316021, ChinaDepartment of Molecular Genetics and Microbiology, Duke University, Durham, 27705, USAState Key Laboratory (SKL) of Biobased Transportation Fuel Technology, Ocean College, Zhejiang University, Hangzhou, 316021, ChinaState Key Laboratory (SKL) of Biobased Transportation Fuel Technology, Ocean College, Zhejiang University, Hangzhou, 316021, ChinaLishui University, Lishui, 323000, ChinaState Key Laboratory (SKL) of Biobased Transportation Fuel Technology, Ocean College, Zhejiang University, Hangzhou, 316021, China; Corresponding author.While genomic alterations are fundamental to biological evolution, enabling adaptation and diversity, they can also result in detrimental outcomes, such as the development of genetic diseases including cancer. The budding yeast Saccharomyces cerevisiae serves as an exemplary model for investigating the mechanisms behind various genomic alterations, including point mutations, chromosomal rearrangements, and whole-chromosome aneuploidy. In this review, we highlight the application of genetic screening systems to assess the mutagenic effects of physical and chemical agents efficiently. Additionally, we discuss the utilization of high-throughput sequencing technologies to uncover comprehensive genomic alterations and rare genetic events. We provide a detailed summary of the features of genomic alterations and discuss the genetic mechanisms driving these changes under both spontaneous and stress-induced conditions. Given the high conservation of DNA replication and repair machinery across different organisms, the insights gained from studies on yeast offer valuable perspectives for understanding the delicate balance between genome plasticity and integrity in other species.http://www.sciencedirect.com/science/article/pii/S2772892724000646Spontaneous genomic alterationsEnvironment induced mutationsYeast modelAdaptationWhole-genome sequencing |
| spellingShingle | Ke-Jing Li Lei Qi Ying-Xuan Zhu Min He Qian Xiang Dao-Qiong Zheng Spontaneous and environment induced genomic alterations in yeast model Cell Insight Spontaneous genomic alterations Environment induced mutations Yeast model Adaptation Whole-genome sequencing |
| title | Spontaneous and environment induced genomic alterations in yeast model |
| title_full | Spontaneous and environment induced genomic alterations in yeast model |
| title_fullStr | Spontaneous and environment induced genomic alterations in yeast model |
| title_full_unstemmed | Spontaneous and environment induced genomic alterations in yeast model |
| title_short | Spontaneous and environment induced genomic alterations in yeast model |
| title_sort | spontaneous and environment induced genomic alterations in yeast model |
| topic | Spontaneous genomic alterations Environment induced mutations Yeast model Adaptation Whole-genome sequencing |
| url | http://www.sciencedirect.com/science/article/pii/S2772892724000646 |
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