Chemosensitivity of Anaplastic Thyroid Cancer Based on a Histoculture Drug Response Assay
The chemosensitivity of anaplastic thyroid cancer (ATC) to some cytotoxic agents was investigated by the histoculture drug response assay (HDRA). Thirty specimens from 22 patients with ATC were obtained from surgically resected subjects. The drugs tested were paclitaxel (PTX), docetaxel (...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/967286 |
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| _version_ | 1832556877829898240 |
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| author | Takashi Uruno Chie Masaki Junko Akaishi Kenichi Matsuzu Akifumi Suzuki Keiko Ohkuwa Hiroshi Shibuya Wataru Kitagawa Mitsuji Nagahama Kiminori Sugino Koichi Ito |
| author_facet | Takashi Uruno Chie Masaki Junko Akaishi Kenichi Matsuzu Akifumi Suzuki Keiko Ohkuwa Hiroshi Shibuya Wataru Kitagawa Mitsuji Nagahama Kiminori Sugino Koichi Ito |
| author_sort | Takashi Uruno |
| collection | DOAJ |
| description | The chemosensitivity of anaplastic thyroid cancer (ATC) to some cytotoxic agents was investigated by
the histoculture drug response assay (HDRA). Thirty specimens from 22 patients with ATC were obtained
from surgically resected subjects. The drugs tested were paclitaxel (PTX), docetaxel (DOC), adriamycin (ADM),
nedaplatin (254-S), cisplatin (CDDP), carboplatin (CBDCA), etoposide (VP-16), 5-fluorouracil (5-FU), mitomycin
C (MMC), and cyclophosphamide (CPA). PTX was the most effective agent, and 25 of 29 cases (86.2%)
had high inhibition rates (IRs; over 70%), while DOC, another taxane, had lower IRs (median, 32.6%).
254-S had the second highest IR (median 68.1%), higher than other platins, CDDP (median 47.3%) and
CBDCA (median 27.4%). The IR of 50% dose PTX (20 μg/mL, median 30.6%) was
markedly decreased, while that of 50% dose 254-S (10 μg/mL, median 63.3%) still
retained its inhibition effect compared to 100% dose. Most recurrent samples had higher IRs than primary
lesions, but the IRs of different drugs differed between primary and recurrent lesions, even with samples from the
same patients. PTX has a higher IR to ATC tissues in the HDRA, which suggests that it may be a key drug
for the treatment of patients with ATC. |
| format | Article |
| id | doaj-art-40b05116591c48779459115b4e6d93c9 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-40b05116591c48779459115b4e6d93c92025-02-03T05:44:07ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/967286967286Chemosensitivity of Anaplastic Thyroid Cancer Based on a Histoculture Drug Response AssayTakashi Uruno0Chie Masaki1Junko Akaishi2Kenichi Matsuzu3Akifumi Suzuki4Keiko Ohkuwa5Hiroshi Shibuya6Wataru Kitagawa7Mitsuji Nagahama8Kiminori Sugino9Koichi Ito10Department of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanDepartment of Surgery, Ito Hospital, 4-3-6 Jingumae, Shibuya-ku, Tokyo 150-8308, JapanThe chemosensitivity of anaplastic thyroid cancer (ATC) to some cytotoxic agents was investigated by the histoculture drug response assay (HDRA). Thirty specimens from 22 patients with ATC were obtained from surgically resected subjects. The drugs tested were paclitaxel (PTX), docetaxel (DOC), adriamycin (ADM), nedaplatin (254-S), cisplatin (CDDP), carboplatin (CBDCA), etoposide (VP-16), 5-fluorouracil (5-FU), mitomycin C (MMC), and cyclophosphamide (CPA). PTX was the most effective agent, and 25 of 29 cases (86.2%) had high inhibition rates (IRs; over 70%), while DOC, another taxane, had lower IRs (median, 32.6%). 254-S had the second highest IR (median 68.1%), higher than other platins, CDDP (median 47.3%) and CBDCA (median 27.4%). The IR of 50% dose PTX (20 μg/mL, median 30.6%) was markedly decreased, while that of 50% dose 254-S (10 μg/mL, median 63.3%) still retained its inhibition effect compared to 100% dose. Most recurrent samples had higher IRs than primary lesions, but the IRs of different drugs differed between primary and recurrent lesions, even with samples from the same patients. PTX has a higher IR to ATC tissues in the HDRA, which suggests that it may be a key drug for the treatment of patients with ATC.http://dx.doi.org/10.1155/2015/967286 |
| spellingShingle | Takashi Uruno Chie Masaki Junko Akaishi Kenichi Matsuzu Akifumi Suzuki Keiko Ohkuwa Hiroshi Shibuya Wataru Kitagawa Mitsuji Nagahama Kiminori Sugino Koichi Ito Chemosensitivity of Anaplastic Thyroid Cancer Based on a Histoculture Drug Response Assay International Journal of Endocrinology |
| title | Chemosensitivity of Anaplastic Thyroid Cancer Based on a Histoculture Drug Response Assay |
| title_full | Chemosensitivity of Anaplastic Thyroid Cancer Based on a Histoculture Drug Response Assay |
| title_fullStr | Chemosensitivity of Anaplastic Thyroid Cancer Based on a Histoculture Drug Response Assay |
| title_full_unstemmed | Chemosensitivity of Anaplastic Thyroid Cancer Based on a Histoculture Drug Response Assay |
| title_short | Chemosensitivity of Anaplastic Thyroid Cancer Based on a Histoculture Drug Response Assay |
| title_sort | chemosensitivity of anaplastic thyroid cancer based on a histoculture drug response assay |
| url | http://dx.doi.org/10.1155/2015/967286 |
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