Retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in Japanese patients with diabetes mellitus
ABSTRACT Aims/Introduction This study aimed to investigate the risk factors for diabetic retinopathy (DR) and diabetic kidney disease (DKD) in Japanese patients with diabetes mellitus (DM). Identifying these factors could provide insights into the shared and distinct mechanisms contributing to these...
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Wiley
2025-01-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.14341 |
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| author | Kota Yamada Mitsuru Ohsugi Yuichiro Ito Hiroki Uchida Takumi Lee Kohjiro Ueki |
| author_facet | Kota Yamada Mitsuru Ohsugi Yuichiro Ito Hiroki Uchida Takumi Lee Kohjiro Ueki |
| author_sort | Kota Yamada |
| collection | DOAJ |
| description | ABSTRACT Aims/Introduction This study aimed to investigate the risk factors for diabetic retinopathy (DR) and diabetic kidney disease (DKD) in Japanese patients with diabetes mellitus (DM). Identifying these factors could provide insights into the shared and distinct mechanisms contributing to these complications in the diabetic population. Materials and Methods We conducted a retrospective analysis using the J‐DREAMS (Japan Diabetes compREhensive database project based on an Advanced electronic Medical record System) database, which is directly linked to electronic medical records. The study included Japanese people aged 18 years and older with diabetes, who were registered at a referral center between December 1, 2015, and March 31, 2021, and had simultaneous measurements of serum creatinine and hemoglobin A1c (HbA1c). The presence or absence of DR and DKD was determined for 8,794 and 8,770 patients, respectively. Multivariable logistic regression analyses were used to identify risk factors, considering patient characteristics, comorbid conditions, and laboratory data as explanatory variables. Results Common risk factors for both DR and DKD included hypertension, anemia, diabetic neuropathy, cerebrovascular disease, chronic heart failure, low serum albumin levels, and elevated HbA1c. The contributions of age, duration of DM, and body mass index (BMI) differed between the DR and DKD groups. Conclusions In addition to poor glycemic control and hypertension, anemia, low serum albumin, cerebrovascular disease, and heart failure were identified as independent common risk factors for DR and DKD, suggesting the existence of cardio‐renal anemia syndrome in patients with DM. |
| format | Article |
| id | doaj-art-409f66a6434a4fb9822c2df89650c84c |
| institution | DOAJ |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Journal of Diabetes Investigation |
| spelling | doaj-art-409f66a6434a4fb9822c2df89650c84c2025-08-20T02:57:40ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-01-0116112012810.1111/jdi.14341Retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in Japanese patients with diabetes mellitusKota Yamada0Mitsuru Ohsugi1Yuichiro Ito2Hiroki Uchida3Takumi Lee4Kohjiro Ueki5Department of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanMedical Affairs Astellas Pharma Inc. Tokyo JapanMedical Affairs Astellas Pharma Inc. Tokyo JapanDevelopment Astellas Pharma Inc. Tokyo JapanDepartment of Diabetes, Endocrinology and Metabolism, Center Hospital National Center for Global Health and Medicine Tokyo JapanABSTRACT Aims/Introduction This study aimed to investigate the risk factors for diabetic retinopathy (DR) and diabetic kidney disease (DKD) in Japanese patients with diabetes mellitus (DM). Identifying these factors could provide insights into the shared and distinct mechanisms contributing to these complications in the diabetic population. Materials and Methods We conducted a retrospective analysis using the J‐DREAMS (Japan Diabetes compREhensive database project based on an Advanced electronic Medical record System) database, which is directly linked to electronic medical records. The study included Japanese people aged 18 years and older with diabetes, who were registered at a referral center between December 1, 2015, and March 31, 2021, and had simultaneous measurements of serum creatinine and hemoglobin A1c (HbA1c). The presence or absence of DR and DKD was determined for 8,794 and 8,770 patients, respectively. Multivariable logistic regression analyses were used to identify risk factors, considering patient characteristics, comorbid conditions, and laboratory data as explanatory variables. Results Common risk factors for both DR and DKD included hypertension, anemia, diabetic neuropathy, cerebrovascular disease, chronic heart failure, low serum albumin levels, and elevated HbA1c. The contributions of age, duration of DM, and body mass index (BMI) differed between the DR and DKD groups. Conclusions In addition to poor glycemic control and hypertension, anemia, low serum albumin, cerebrovascular disease, and heart failure were identified as independent common risk factors for DR and DKD, suggesting the existence of cardio‐renal anemia syndrome in patients with DM.https://doi.org/10.1111/jdi.14341Cardio‐renal anemia syndromeDiabetic kidney diseaseDiabetic retinopathy |
| spellingShingle | Kota Yamada Mitsuru Ohsugi Yuichiro Ito Hiroki Uchida Takumi Lee Kohjiro Ueki Retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in Japanese patients with diabetes mellitus Journal of Diabetes Investigation Cardio‐renal anemia syndrome Diabetic kidney disease Diabetic retinopathy |
| title | Retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in Japanese patients with diabetes mellitus |
| title_full | Retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in Japanese patients with diabetes mellitus |
| title_fullStr | Retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in Japanese patients with diabetes mellitus |
| title_full_unstemmed | Retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in Japanese patients with diabetes mellitus |
| title_short | Retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in Japanese patients with diabetes mellitus |
| title_sort | retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in japanese patients with diabetes mellitus |
| topic | Cardio‐renal anemia syndrome Diabetic kidney disease Diabetic retinopathy |
| url | https://doi.org/10.1111/jdi.14341 |
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