Tissue Anisotropy Modeling Using Soft Composite Materials
Soft tissues in general exhibit anisotropic mechanical behavior, which varies in three dimensions based on the location of the tissue in the body. In the past, there have been few attempts to numerically model tissue anisotropy using composite-based formulations (involving fibers embedded within a m...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2018/4838157 |
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| author | Arnab Chanda Christian Callaway |
| author_facet | Arnab Chanda Christian Callaway |
| author_sort | Arnab Chanda |
| collection | DOAJ |
| description | Soft tissues in general exhibit anisotropic mechanical behavior, which varies in three dimensions based on the location of the tissue in the body. In the past, there have been few attempts to numerically model tissue anisotropy using composite-based formulations (involving fibers embedded within a matrix material). However, so far, tissue anisotropy has not been modeled experimentally. In the current work, novel elastomer-based soft composite materials were developed in the form of experimental test coupons, to model the macroscopic anisotropy in tissue mechanical properties. A soft elastomer matrix was fabricated, and fibers made of a stiffer elastomer material were embedded within the matrix material to generate the test coupons. The coupons were tested on a mechanical testing machine, and the resulting stress-versus-stretch responses were studied. The fiber volume fraction (FVF), fiber spacing, and orientations were varied to estimate the changes in the mechanical responses. The mechanical behavior of the soft composites was characterized using hyperelastic material models such as Mooney-Rivlin’s, Humphrey’s, and Veronda-Westmann’s model and also compared with the anisotropic mechanical behavior of the human skin, pelvic tissues, and brain tissues. This work lays the foundation for the experimental modelling of tissue anisotropy, which combined with microscopic studies on tissues can lead to refinements in the simulation of localized fiber distribution and orientations, and enable the development of biofidelic anisotropic tissue phantom materials for various tissue engineering and testing applications. |
| format | Article |
| id | doaj-art-40840a2c3aef4c8395553371335dd565 |
| institution | Kabale University |
| issn | 1176-2322 1754-2103 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-40840a2c3aef4c8395553371335dd5652025-02-03T01:01:43ZengWileyApplied Bionics and Biomechanics1176-23221754-21032018-01-01201810.1155/2018/48381574838157Tissue Anisotropy Modeling Using Soft Composite MaterialsArnab Chanda0Christian Callaway1Department of Aerospace Engineering, University of Alabama, Tuscaloosa, AL 35401, USADepartment of Aerospace Engineering, University of Alabama, Tuscaloosa, AL 35401, USASoft tissues in general exhibit anisotropic mechanical behavior, which varies in three dimensions based on the location of the tissue in the body. In the past, there have been few attempts to numerically model tissue anisotropy using composite-based formulations (involving fibers embedded within a matrix material). However, so far, tissue anisotropy has not been modeled experimentally. In the current work, novel elastomer-based soft composite materials were developed in the form of experimental test coupons, to model the macroscopic anisotropy in tissue mechanical properties. A soft elastomer matrix was fabricated, and fibers made of a stiffer elastomer material were embedded within the matrix material to generate the test coupons. The coupons were tested on a mechanical testing machine, and the resulting stress-versus-stretch responses were studied. The fiber volume fraction (FVF), fiber spacing, and orientations were varied to estimate the changes in the mechanical responses. The mechanical behavior of the soft composites was characterized using hyperelastic material models such as Mooney-Rivlin’s, Humphrey’s, and Veronda-Westmann’s model and also compared with the anisotropic mechanical behavior of the human skin, pelvic tissues, and brain tissues. This work lays the foundation for the experimental modelling of tissue anisotropy, which combined with microscopic studies on tissues can lead to refinements in the simulation of localized fiber distribution and orientations, and enable the development of biofidelic anisotropic tissue phantom materials for various tissue engineering and testing applications.http://dx.doi.org/10.1155/2018/4838157 |
| spellingShingle | Arnab Chanda Christian Callaway Tissue Anisotropy Modeling Using Soft Composite Materials Applied Bionics and Biomechanics |
| title | Tissue Anisotropy Modeling Using Soft Composite Materials |
| title_full | Tissue Anisotropy Modeling Using Soft Composite Materials |
| title_fullStr | Tissue Anisotropy Modeling Using Soft Composite Materials |
| title_full_unstemmed | Tissue Anisotropy Modeling Using Soft Composite Materials |
| title_short | Tissue Anisotropy Modeling Using Soft Composite Materials |
| title_sort | tissue anisotropy modeling using soft composite materials |
| url | http://dx.doi.org/10.1155/2018/4838157 |
| work_keys_str_mv | AT arnabchanda tissueanisotropymodelingusingsoftcompositematerials AT christiancallaway tissueanisotropymodelingusingsoftcompositematerials |