Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross‐Sectional Study
ABSTRACT Background and Aims Mounting evidence have implicated that rs1801131 and rs1801133, located in the Methylenetetrahydrofolate reductase (MTHFR) gene, may emerge as novel biomarkers for coronary artery disease (CAD). The Synergy between Percutaneous Coronary Intervention with Taxus and Cardia...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70284 |
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| author | Behnam Nazarzadeh Saeedeh sadat Ghazanfari Farzaneh Karimi Seyed ali Moezibady Fatemeh Salmani Kazem Dastjerdi Hamidreza Mohammadi |
| author_facet | Behnam Nazarzadeh Saeedeh sadat Ghazanfari Farzaneh Karimi Seyed ali Moezibady Fatemeh Salmani Kazem Dastjerdi Hamidreza Mohammadi |
| author_sort | Behnam Nazarzadeh |
| collection | DOAJ |
| description | ABSTRACT Background and Aims Mounting evidence have implicated that rs1801131 and rs1801133, located in the Methylenetetrahydrofolate reductase (MTHFR) gene, may emerge as novel biomarkers for coronary artery disease (CAD). The Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score is also an appropriate predictor for revascularization strategy in patients with complex CAD. The aim of this study is to investigate the correlation between rs1801131 and rs1801133 with the severity of coronary lesions in patients with ST‑Elevation Myocardial Infarction (STEMI) and Non‑ST‑Elevation Myocardial Infarction (NSTEMI) based on the SYNTAX score. Methods This retrospective cross‐sectional study included 96 patients diagnosed with STEMI and NSTEMI from Razi University Hospital between April and September 2019. Ninety‐six patients were diagnosed with STEMI (N = 43) and NSTEMI (N = 53) were recruited from South Khorasan, Iran. The angiographical characteristics of CAD were defined by the SYNTAX score. Genomic DNA was isolated from peripheral blood and genotyped for rs1801131 and rs1801133 using the TaqMan real‐time PCR method. Results The results of the one‐way analysis of variance indicated that there is no association between rs1801131 and rs1801133 with the severity of coronary lesions in patients with STEMI (p = 0.44) and NSTEMI (p = 0.91). However, the two‐way analysis of variance comparison and post‐hoc test demonstrated that rs1801133 in the presence of rs1801131 is correlated with the SYNTAX score in NSTEMI (p = 0.03) and total patients (p = 0.03). Conclusion In conclusion, our study reveals a significant association between the MTHFR polymorphism rs1801133 and CAD severity, particularly in NSTEMI patients. While rs1801131 showed no correlation, rs1801133 may serve as a valuable genetic biomarker for assessing CAD severity. Further research with larger populations is needed to confirm these findings. |
| format | Article |
| id | doaj-art-407721e3fa004e4dbe30eedbd5aa60fb |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-407721e3fa004e4dbe30eedbd5aa60fb2025-01-29T03:42:40ZengWileyHealth Science Reports2398-88352025-01-0181n/an/a10.1002/hsr2.70284Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross‐Sectional StudyBehnam Nazarzadeh0Saeedeh sadat Ghazanfari1Farzaneh Karimi2Seyed ali Moezibady3Fatemeh Salmani4Kazem Dastjerdi5Hamidreza Mohammadi6Department of Medical Biotechnology, Faculty of Medicine Birjand University of Medical Sciences Birjand IranMashhad University of Medical Sciences Mashhad Branch Islamic Azad University Mashhad IranInstitute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald University of Greifswald Greifswald GermanyRazi Clinical Research Development Unit (RCRDU) Birjand University of Medical Sciences Birjand IranSocial Determinants of Health Research Center, Department of Epidemiology and Biostatistics, School of Health Birjand University of Medical Sciences Birjand IranDepartment of Medical Biotechnology, Faculty of Medicine Birjand University of Medical Sciences Birjand IranYazd Cardiovascular Research Center, Non‐communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd IranABSTRACT Background and Aims Mounting evidence have implicated that rs1801131 and rs1801133, located in the Methylenetetrahydrofolate reductase (MTHFR) gene, may emerge as novel biomarkers for coronary artery disease (CAD). The Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score is also an appropriate predictor for revascularization strategy in patients with complex CAD. The aim of this study is to investigate the correlation between rs1801131 and rs1801133 with the severity of coronary lesions in patients with ST‑Elevation Myocardial Infarction (STEMI) and Non‑ST‑Elevation Myocardial Infarction (NSTEMI) based on the SYNTAX score. Methods This retrospective cross‐sectional study included 96 patients diagnosed with STEMI and NSTEMI from Razi University Hospital between April and September 2019. Ninety‐six patients were diagnosed with STEMI (N = 43) and NSTEMI (N = 53) were recruited from South Khorasan, Iran. The angiographical characteristics of CAD were defined by the SYNTAX score. Genomic DNA was isolated from peripheral blood and genotyped for rs1801131 and rs1801133 using the TaqMan real‐time PCR method. Results The results of the one‐way analysis of variance indicated that there is no association between rs1801131 and rs1801133 with the severity of coronary lesions in patients with STEMI (p = 0.44) and NSTEMI (p = 0.91). However, the two‐way analysis of variance comparison and post‐hoc test demonstrated that rs1801133 in the presence of rs1801131 is correlated with the SYNTAX score in NSTEMI (p = 0.03) and total patients (p = 0.03). Conclusion In conclusion, our study reveals a significant association between the MTHFR polymorphism rs1801133 and CAD severity, particularly in NSTEMI patients. While rs1801131 showed no correlation, rs1801133 may serve as a valuable genetic biomarker for assessing CAD severity. Further research with larger populations is needed to confirm these findings.https://doi.org/10.1002/hsr2.70284coronary artery diseaseMTHFRRs1801131Rs1801133 |
| spellingShingle | Behnam Nazarzadeh Saeedeh sadat Ghazanfari Farzaneh Karimi Seyed ali Moezibady Fatemeh Salmani Kazem Dastjerdi Hamidreza Mohammadi Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross‐Sectional Study Health Science Reports coronary artery disease MTHFR Rs1801131 Rs1801133 |
| title | Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross‐Sectional Study |
| title_full | Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross‐Sectional Study |
| title_fullStr | Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross‐Sectional Study |
| title_full_unstemmed | Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross‐Sectional Study |
| title_short | Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTEMI: A Retrospective Cross‐Sectional Study |
| title_sort | evaluating the association between methylenetetrahydrofolate reductase rs1801131 and rs1801133 gene polymorphisms and severity of coronary lesions in patients with stemi and nstemi a retrospective cross sectional study |
| topic | coronary artery disease MTHFR Rs1801131 Rs1801133 |
| url | https://doi.org/10.1002/hsr2.70284 |
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