Efficient pH-sensitive nanosystem containing Atractylenolide Ⅰ for improving tumor hypoxic microenvironment and photothermal conversion capability for synergistic treatment of colorectal cancer

Efficient pH-sensitive nanosystem containing Atractylenolide Ⅰ for improving tumor hypoxic microenvironment and photothermal conversion capability for synergistic treatment of colorectal cancer

BackgroundPhotodynamic therapy (PDT) displays several beneficial characteristics, but it is still limited by the poor water solubility of photosensitizers, the insufficient targetability of the system, and the hypoxic microenvironment of tumors. It has been demonstrated that Atractylenolide Ⅰ(ATL-1)...

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Bibliographic Details
Main Authors: Yuqing Zhu, Qiang Ye, Shi Feng, Xiujuan Fu, Siwei Chen, Hao Liu, Jialin Ning, Yaling Li, Dan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Nanotechnology
Subjects:
CRC
ATL-1
Ce6
pH sensitive liposome
PDT
Online Access:https://www.frontiersin.org/articles/10.3389/fnano.2025.1587439/full
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