Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain
Left-right asymmetry of the human brain is widespread through its anatomy and function. However, limited microscopic understanding of it exists, particularly for anatomical asymmetry where there are few well-established animal models. In humans, most brain regions show subtle, population-average reg...
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Elsevier
2025-02-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925000175 |
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| author | Andrew Silberfeld James M. Roe Jacob Ellegood Jason P. Lerch Lily Qiu Yongsoo Kim Jong Gwan Lee William D. Hopkins Joanes Grandjean Yangming Ou Olivier Pourquié |
| author_facet | Andrew Silberfeld James M. Roe Jacob Ellegood Jason P. Lerch Lily Qiu Yongsoo Kim Jong Gwan Lee William D. Hopkins Joanes Grandjean Yangming Ou Olivier Pourquié |
| author_sort | Andrew Silberfeld |
| collection | DOAJ |
| description | Left-right asymmetry of the human brain is widespread through its anatomy and function. However, limited microscopic understanding of it exists, particularly for anatomical asymmetry where there are few well-established animal models. In humans, most brain regions show subtle, population-average regional asymmetries in thickness or surface area, alongside a macro-scale twisting called the cerebral petalia in which the right hemisphere protrudes past the left. Here, we ask whether neuroanatomical asymmetries can be observed in mice, leveraging 6 mouse neuroimaging cohorts from 5 different research groups (∼3,500 animals). We found an anterior-posterior pattern of volume asymmetry with anterior regions larger on the right and posterior regions larger on the left. This pattern appears driven by similar trends in surface area and positional asymmetries, with the results together indicating a small brain-wide twisting pattern, similar to the human cerebral petalia. Furthermore, the results show no apparent relationship to known functional asymmetries in mice, emphasizing the complexity of the structure-function relationship in brain asymmetry. Our results recapitulate and extend previous patterns of asymmetry from two published studies as well as capture well-established, bilateral male-female differences in the mouse brain as a positive control. By establishing a signature of anatomical brain asymmetry in mice, we aim to provide a foundation for future studies to probe the mechanistic underpinnings of brain asymmetry seen in humans – a feature of the brain with extremely limited understanding. |
| format | Article |
| id | doaj-art-4070d622bc9a45b7b31b715e9ab2ded9 |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-4070d622bc9a45b7b31b715e9ab2ded92025-02-06T05:11:06ZengElsevierNeuroImage1095-95722025-02-01307121017Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse BrainAndrew Silberfeld0James M. Roe1Jacob Ellegood2Jason P. Lerch3Lily Qiu4Yongsoo Kim5Jong Gwan Lee6William D. Hopkins7Joanes Grandjean8Yangming Ou9Olivier Pourquié10Department of Genetics, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USACenter for Lifespan Changes in Brain and Cognition (LCBC), Department of Psychology, University of Oslo, NorwayBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada; Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, CanadaMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, The University of Toronto, Toronto, ON, Canada; Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada; Department of Preclinical Imaging, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UKMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, CanadaDepartment of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA, USADepartment of Genetics, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USADepartment of Comparative Medicine & Michale E Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, United StatesDonders Institute for Brain, Behaviour, and Cognition, Nijmegen, Netherlands; Department for Medical Imaging, Radboud University Medical Center, PO Box 9101, Nijmegen, NetherlandsBoston Children's Hospital, Harvard Medical School, Harvard University, Boston, MA, USADepartment of Genetics, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA; Corresponding author.Left-right asymmetry of the human brain is widespread through its anatomy and function. However, limited microscopic understanding of it exists, particularly for anatomical asymmetry where there are few well-established animal models. In humans, most brain regions show subtle, population-average regional asymmetries in thickness or surface area, alongside a macro-scale twisting called the cerebral petalia in which the right hemisphere protrudes past the left. Here, we ask whether neuroanatomical asymmetries can be observed in mice, leveraging 6 mouse neuroimaging cohorts from 5 different research groups (∼3,500 animals). We found an anterior-posterior pattern of volume asymmetry with anterior regions larger on the right and posterior regions larger on the left. This pattern appears driven by similar trends in surface area and positional asymmetries, with the results together indicating a small brain-wide twisting pattern, similar to the human cerebral petalia. Furthermore, the results show no apparent relationship to known functional asymmetries in mice, emphasizing the complexity of the structure-function relationship in brain asymmetry. Our results recapitulate and extend previous patterns of asymmetry from two published studies as well as capture well-established, bilateral male-female differences in the mouse brain as a positive control. By establishing a signature of anatomical brain asymmetry in mice, we aim to provide a foundation for future studies to probe the mechanistic underpinnings of brain asymmetry seen in humans – a feature of the brain with extremely limited understanding.http://www.sciencedirect.com/science/article/pii/S1053811925000175MouseBrainAsymmetryLateralizationHemisphereLeft-right |
| spellingShingle | Andrew Silberfeld James M. Roe Jacob Ellegood Jason P. Lerch Lily Qiu Yongsoo Kim Jong Gwan Lee William D. Hopkins Joanes Grandjean Yangming Ou Olivier Pourquié Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain NeuroImage Mouse Brain Asymmetry Lateralization Hemisphere Left-right |
| title | Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain |
| title_full | Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain |
| title_fullStr | Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain |
| title_full_unstemmed | Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain |
| title_short | Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain |
| title_sort | left right brain wide asymmetry of neuroanatomy in the mouse brain |
| topic | Mouse Brain Asymmetry Lateralization Hemisphere Left-right |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925000175 |
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