Catalytic pathways for N-arylation of benzimidazoles: A comprehensive review
The N-arylated benzimidazoles are important structural motifs in many biologically active compounds. Due to their distinct physicochemical and structural features, they have applications in a wide range of domains, including pharmaceutical chemistry, material sciences, and catalysis. Synthetic chemi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625000268 |
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| Summary: | The N-arylated benzimidazoles are important structural motifs in many biologically active compounds. Due to their distinct physicochemical and structural features, they have applications in a wide range of domains, including pharmaceutical chemistry, material sciences, and catalysis. Synthetic chemists have devised a variety of methods to accomplish efficient N-arylation of benzimidazoles. Transition metal-based catalysis has emerged as a key strategy, utilizing metals such as copper (Cu), palladium (Pd), iron (Fe), nickel (Ni), iridium (Ir), and ruthenium (Ru). These catalysts, which are frequently supported by a variety of ligands, allow for the selective and efficient production of N-aryl bonds under a wide range of reaction conditions. Cross-coupling reactions, such as the Chan-Lam, Ullmann, and Buchwald-Hartwig protocols, are commonly used due to their durability and scalability. Metal-free techniques offer ecologically friendly options, and multicomponent reactions provide the benefit of convergent synthesis. Microwave-assisted reactions and photocatalyzed procedures have improved the efficiency, selectivity, and sustainability of N-arylation reactions. The review provides a comprehensive overview of the recent advancements and strategies employed in constructing this important class of heterocyclic compounds, highlighting their versatility and significance. |
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| ISSN: | 2211-7156 |