Possible Nonopioid-Mediated Analgesia Produced by Methotrimeprazine in Rats

BACKGROUND: Several reports in the 1960s demonstrated that methotrimeprazine (MTMZ), a phenothiazine derivative, is effective for treating acute and chronic pain. Although MTMZ has received little attention in recent decades, the fact that it derives from a class of drugs usually associated with cog...

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Bibliographic Details
Main Authors: Perry N Fuchs, Bradley Kerr, Ronald Melzack
Format: Article
Language:English
Published: Wiley 1996-01-01
Series:Pain Research and Management
Online Access:http://dx.doi.org/10.1155/1996/631681
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Summary:BACKGROUND: Several reports in the 1960s demonstrated that methotrimeprazine (MTMZ), a phenothiazine derivative, is effective for treating acute and chronic pain. Although MTMZ has received little attention in recent decades, the fact that it derives from a class of drugs usually associated with cognitive and emotional processes, rather than the traditional analgesics, makes it interesting as a potential source of information about the mechanisms of analgesia.
ISSN:1203-6765