The Effect of Propofol on Chronic Headaches in Patients Undergoing Endoscopy
Objective. This study determined acute and long-term effects of propofol administration in patients with severe headaches undergoing endoscopic procedures. Background. Approximately 13% of the US population is affected by migraines or severe headaches. The effect of propofol on headaches more than a...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2018/6018404 |
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| _version_ | 1832552632475975680 |
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| author | David Giampetro Victor Ruiz-Velasco Ashlee Pruett Matthew Wicklund Robert Knipe |
| author_facet | David Giampetro Victor Ruiz-Velasco Ashlee Pruett Matthew Wicklund Robert Knipe |
| author_sort | David Giampetro |
| collection | DOAJ |
| description | Objective. This study determined acute and long-term effects of propofol administration in patients with severe headaches undergoing endoscopic procedures. Background. Approximately 13% of the US population is affected by migraines or severe headaches. The effect of propofol on headaches more than a few days after the intervention has not been explored. Methods. We employed a nonrandomized, prospective observational study that recruited patients with chronic headaches who received propofol from an outpatient endoscopy center for either upper or lower endoscopies. Patients completed the six-item Headache Impact Test (HIT-6) questionnaire prior to the procedure and 30 days after endoscopy. Additionally, the patients’ response to propofol two days after endoscopy was assessed via phone. Results. The age of the participants (n=31) ranged from 20 to 70 years. The mean HIT-6 composite scores were significantly lower (p<0.05) 30 days after propofol administration when compared to baseline scores. Upon stratification, 23 patients indicated an improved condition, 7 a worsened outcome, and 1 showed no change. Furthermore, mean scores were significantly lower (p<0.05) in three HIT-6 questions pertaining to the severity of pain, daily activity, and frequency of lying down. Finally, the mean pain score obtained was significantly lower (p<0.05) two days after procedure. Conclusions. The results of this suggest that propofol administration should be considered in treating chronic headaches. Double-blind studies are necessary to confirm these results. |
| format | Article |
| id | doaj-art-40571217a436457cae36fc074931c794 |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-40571217a436457cae36fc074931c7942025-02-03T05:58:12ZengWileyPain Research and Management1203-67651918-15232018-01-01201810.1155/2018/60184046018404The Effect of Propofol on Chronic Headaches in Patients Undergoing EndoscopyDavid Giampetro0Victor Ruiz-Velasco1Ashlee Pruett2Matthew Wicklund3Robert Knipe4Penn State Hershey Medical Center, Department of Anesthesiology and Perioperative Medicine, Hershey, PA, USAPenn State Hershey Medical Center, Department of Anesthesiology and Perioperative Medicine, Hershey, PA, USAPenn State Hershey Medical Center, Department of Anesthesiology and Perioperative Medicine, Hershey, PA, USADepartment of Neurology, University of Colorado, Aurora, CO, USAPenn State Hershey Medical Center, Department of Anesthesiology and Perioperative Medicine, Hershey, PA, USAObjective. This study determined acute and long-term effects of propofol administration in patients with severe headaches undergoing endoscopic procedures. Background. Approximately 13% of the US population is affected by migraines or severe headaches. The effect of propofol on headaches more than a few days after the intervention has not been explored. Methods. We employed a nonrandomized, prospective observational study that recruited patients with chronic headaches who received propofol from an outpatient endoscopy center for either upper or lower endoscopies. Patients completed the six-item Headache Impact Test (HIT-6) questionnaire prior to the procedure and 30 days after endoscopy. Additionally, the patients’ response to propofol two days after endoscopy was assessed via phone. Results. The age of the participants (n=31) ranged from 20 to 70 years. The mean HIT-6 composite scores were significantly lower (p<0.05) 30 days after propofol administration when compared to baseline scores. Upon stratification, 23 patients indicated an improved condition, 7 a worsened outcome, and 1 showed no change. Furthermore, mean scores were significantly lower (p<0.05) in three HIT-6 questions pertaining to the severity of pain, daily activity, and frequency of lying down. Finally, the mean pain score obtained was significantly lower (p<0.05) two days after procedure. Conclusions. The results of this suggest that propofol administration should be considered in treating chronic headaches. Double-blind studies are necessary to confirm these results.http://dx.doi.org/10.1155/2018/6018404 |
| spellingShingle | David Giampetro Victor Ruiz-Velasco Ashlee Pruett Matthew Wicklund Robert Knipe The Effect of Propofol on Chronic Headaches in Patients Undergoing Endoscopy Pain Research and Management |
| title | The Effect of Propofol on Chronic Headaches in Patients Undergoing Endoscopy |
| title_full | The Effect of Propofol on Chronic Headaches in Patients Undergoing Endoscopy |
| title_fullStr | The Effect of Propofol on Chronic Headaches in Patients Undergoing Endoscopy |
| title_full_unstemmed | The Effect of Propofol on Chronic Headaches in Patients Undergoing Endoscopy |
| title_short | The Effect of Propofol on Chronic Headaches in Patients Undergoing Endoscopy |
| title_sort | effect of propofol on chronic headaches in patients undergoing endoscopy |
| url | http://dx.doi.org/10.1155/2018/6018404 |
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