Vaginal Primary Malignant Melanoma: A Rare and Aggressive Tumor

Vaginal primary malignant melanoma is a rare and very aggressive tumor. It most commonly occurs in postmenopausal women, with a mean age of 57 years. Our patient is an 80-year-old, postmenopausal Greek woman presented with a complaint of abnormal vaginal bleeding. On gynecologic examination there wa...

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Main Authors: Georgios Androutsopoulos, Emmanouil Terzakis, Georgia Ioannidou, Athanasios Tsamandas, Georgios Decavalas
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Case Reports in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/2013/137908
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author Georgios Androutsopoulos
Emmanouil Terzakis
Georgia Ioannidou
Athanasios Tsamandas
Georgios Decavalas
author_facet Georgios Androutsopoulos
Emmanouil Terzakis
Georgia Ioannidou
Athanasios Tsamandas
Georgios Decavalas
author_sort Georgios Androutsopoulos
collection DOAJ
description Vaginal primary malignant melanoma is a rare and very aggressive tumor. It most commonly occurs in postmenopausal women, with a mean age of 57 years. Our patient is an 80-year-old, postmenopausal Greek woman presented with a complaint of abnormal vaginal bleeding. On gynecologic examination there was a pigmented, raised, ulcerated, and irregular lesion  cm in the upper third of anterior vaginal wall. She underwent a wide local excision of the lesion. The histopathology revealed vaginal primary malignant melanoma with ulceration and no clear surgical margins. She denied any additional surgical interventions and underwent to postoperative adjuvant radiotherapy. Follow up 5 months after initial diagnosis revealed no evidence of local recurrence or distant metastasis. The prognosis of vaginal primary malignant melanoma is very poor despite treatment modality, because most of the cases are diagnosed at advanced stage. Particularly patients with no clear surgical margins and tumor size >3 cm needed postoperative adjuvant radiotherapy.
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spelling doaj-art-40534f6ff98148b19d57f253f57c2a742025-02-03T06:05:11ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922013-01-01201310.1155/2013/137908137908Vaginal Primary Malignant Melanoma: A Rare and Aggressive TumorGeorgios Androutsopoulos0Emmanouil Terzakis1Georgia Ioannidou2Athanasios Tsamandas3Georgios Decavalas4Department of Obstetrics and Gynaecology, University of Patras, Medical School, 26504 Rio, GreeceDepartment of Obstetrics and Gynaecology, University of Patras, Medical School, 26504 Rio, GreeceDepartment of Radiation Oncology, St. Savvas Anticancer-Oncologic Hospital, Athens, GreeceDepartment of Pathology, University of Patras, Medical School, 26504 Rio, GreeceDepartment of Obstetrics and Gynaecology, University of Patras, Medical School, 26504 Rio, GreeceVaginal primary malignant melanoma is a rare and very aggressive tumor. It most commonly occurs in postmenopausal women, with a mean age of 57 years. Our patient is an 80-year-old, postmenopausal Greek woman presented with a complaint of abnormal vaginal bleeding. On gynecologic examination there was a pigmented, raised, ulcerated, and irregular lesion  cm in the upper third of anterior vaginal wall. She underwent a wide local excision of the lesion. The histopathology revealed vaginal primary malignant melanoma with ulceration and no clear surgical margins. She denied any additional surgical interventions and underwent to postoperative adjuvant radiotherapy. Follow up 5 months after initial diagnosis revealed no evidence of local recurrence or distant metastasis. The prognosis of vaginal primary malignant melanoma is very poor despite treatment modality, because most of the cases are diagnosed at advanced stage. Particularly patients with no clear surgical margins and tumor size >3 cm needed postoperative adjuvant radiotherapy.http://dx.doi.org/10.1155/2013/137908
spellingShingle Georgios Androutsopoulos
Emmanouil Terzakis
Georgia Ioannidou
Athanasios Tsamandas
Georgios Decavalas
Vaginal Primary Malignant Melanoma: A Rare and Aggressive Tumor
Case Reports in Obstetrics and Gynecology
title Vaginal Primary Malignant Melanoma: A Rare and Aggressive Tumor
title_full Vaginal Primary Malignant Melanoma: A Rare and Aggressive Tumor
title_fullStr Vaginal Primary Malignant Melanoma: A Rare and Aggressive Tumor
title_full_unstemmed Vaginal Primary Malignant Melanoma: A Rare and Aggressive Tumor
title_short Vaginal Primary Malignant Melanoma: A Rare and Aggressive Tumor
title_sort vaginal primary malignant melanoma a rare and aggressive tumor
url http://dx.doi.org/10.1155/2013/137908
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AT georgiaioannidou vaginalprimarymalignantmelanomaarareandaggressivetumor
AT athanasiostsamandas vaginalprimarymalignantmelanomaarareandaggressivetumor
AT georgiosdecavalas vaginalprimarymalignantmelanomaarareandaggressivetumor