NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness
Neuromyelitis optica (NMO) and myasthenia gravis (MG) are autoimmune diseases mediated by autoantibodies against either aquaporin 4 (AQP4) or acetylcholine receptor (AChR), respectively. Recently, we and others have reported an increased prevalence of NMO in patients with MG. To verify whether coexi...
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| Format: | Article |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5389282 |
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| author | Tehila Mizrachi Livnat Brill Malcolm Rabie Yoram Nevo Yakov Fellig Mayan Zur Dimitrios Karussis Oded Abramsky Talma Brenner Adi Vaknin-Dembinsky |
| author_facet | Tehila Mizrachi Livnat Brill Malcolm Rabie Yoram Nevo Yakov Fellig Mayan Zur Dimitrios Karussis Oded Abramsky Talma Brenner Adi Vaknin-Dembinsky |
| author_sort | Tehila Mizrachi |
| collection | DOAJ |
| description | Neuromyelitis optica (NMO) and myasthenia gravis (MG) are autoimmune diseases mediated by autoantibodies against either aquaporin 4 (AQP4) or acetylcholine receptor (AChR), respectively. Recently, we and others have reported an increased prevalence of NMO in patients with MG. To verify whether coexisting autoimmune disease may exacerbate experimental autoimmune MG, we tested whether active immunization with AQP4 peptides or passive transfer of NMO-Ig can affect the severity of EAMG. Injection of either AQP4 peptide or NMO-Ig to EAMG or to naive mice caused increased fatigability and aggravation of EAMG symptoms as expressed by augmented muscle weakness (but not paralysis), decremental response to repetitive nerve stimulation, increased neuromuscular jitter, and aberration of immune responses. Thus, our study shows increased disease severity in EAMG mice following immunization with the NMO autoantigen AQP4 or by NMO-Ig, mediated by augmented inflammatory response. This can explain exacerbation or increased susceptibility of patients with one autoimmune disease to develop additional autoimmune syndrome. |
| format | Article |
| id | doaj-art-403e8ae6eaa84e13b8a97379aea65d94 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-403e8ae6eaa84e13b8a97379aea65d942025-02-03T01:01:47ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/53892825389282NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle WeaknessTehila Mizrachi0Livnat Brill1Malcolm Rabie2Yoram Nevo3Yakov Fellig4Mayan Zur5Dimitrios Karussis6Oded Abramsky7Talma Brenner8Adi Vaknin-Dembinsky9Department of Neurology and The Multiple Sclerosis Center, The Agnes-Ginges Center for Neurogenetics, Hebrew University, Hadassah Medical Center, Ein Karem, Jerusalem 91120, IsraelDepartment of Neurology and The Multiple Sclerosis Center, The Agnes-Ginges Center for Neurogenetics, Hebrew University, Hadassah Medical Center, Ein Karem, Jerusalem 91120, IsraelSchneider Children’s Medical Center of Israel, Tel Aviv University, Tel Aviv, IsraelSchneider Children’s Medical Center of Israel, Tel Aviv University, Tel Aviv, IsraelDepartment of Neurology and The Multiple Sclerosis Center, The Agnes-Ginges Center for Neurogenetics, Hebrew University, Hadassah Medical Center, Ein Karem, Jerusalem 91120, IsraelDepartment of Neurology and The Multiple Sclerosis Center, The Agnes-Ginges Center for Neurogenetics, Hebrew University, Hadassah Medical Center, Ein Karem, Jerusalem 91120, IsraelDepartment of Neurology and The Multiple Sclerosis Center, The Agnes-Ginges Center for Neurogenetics, Hebrew University, Hadassah Medical Center, Ein Karem, Jerusalem 91120, IsraelDepartment of Neurology and The Multiple Sclerosis Center, The Agnes-Ginges Center for Neurogenetics, Hebrew University, Hadassah Medical Center, Ein Karem, Jerusalem 91120, IsraelDepartment of Neurology and The Multiple Sclerosis Center, The Agnes-Ginges Center for Neurogenetics, Hebrew University, Hadassah Medical Center, Ein Karem, Jerusalem 91120, IsraelDepartment of Neurology and The Multiple Sclerosis Center, The Agnes-Ginges Center for Neurogenetics, Hebrew University, Hadassah Medical Center, Ein Karem, Jerusalem 91120, IsraelNeuromyelitis optica (NMO) and myasthenia gravis (MG) are autoimmune diseases mediated by autoantibodies against either aquaporin 4 (AQP4) or acetylcholine receptor (AChR), respectively. Recently, we and others have reported an increased prevalence of NMO in patients with MG. To verify whether coexisting autoimmune disease may exacerbate experimental autoimmune MG, we tested whether active immunization with AQP4 peptides or passive transfer of NMO-Ig can affect the severity of EAMG. Injection of either AQP4 peptide or NMO-Ig to EAMG or to naive mice caused increased fatigability and aggravation of EAMG symptoms as expressed by augmented muscle weakness (but not paralysis), decremental response to repetitive nerve stimulation, increased neuromuscular jitter, and aberration of immune responses. Thus, our study shows increased disease severity in EAMG mice following immunization with the NMO autoantigen AQP4 or by NMO-Ig, mediated by augmented inflammatory response. This can explain exacerbation or increased susceptibility of patients with one autoimmune disease to develop additional autoimmune syndrome.http://dx.doi.org/10.1155/2018/5389282 |
| spellingShingle | Tehila Mizrachi Livnat Brill Malcolm Rabie Yoram Nevo Yakov Fellig Mayan Zur Dimitrios Karussis Oded Abramsky Talma Brenner Adi Vaknin-Dembinsky NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness Journal of Immunology Research |
| title | NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness |
| title_full | NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness |
| title_fullStr | NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness |
| title_full_unstemmed | NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness |
| title_short | NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness |
| title_sort | nmo igg and aqp4 peptide can induce aggravation of eamg and immune mediated muscle weakness |
| url | http://dx.doi.org/10.1155/2018/5389282 |
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