Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review
Abstract Introduction Laryngeal chondrosarcoma (CS) is a rare indolent malignant tumor. High-grade (G3), dedifferentiated (DD), and myxoid (MY) CSs are considered more aggressive subtypes due to their metastatic potential and relatively poor outcomes. The aim of this systematic review is to evaluate...
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Adis, Springer Healthcare
2025-01-01
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| Series: | Oncology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40487-024-00323-1 |
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| author | Cesare Piazza Claudia Montenegro Michele Tomasoni Ilmo Leivo Göran Stenman Abbas Agaimy Roderick H. W. Simpson Nina Zidar Alfio Ferlito |
| author_facet | Cesare Piazza Claudia Montenegro Michele Tomasoni Ilmo Leivo Göran Stenman Abbas Agaimy Roderick H. W. Simpson Nina Zidar Alfio Ferlito |
| author_sort | Cesare Piazza |
| collection | DOAJ |
| description | Abstract Introduction Laryngeal chondrosarcoma (CS) is a rare indolent malignant tumor. High-grade (G3), dedifferentiated (DD), and myxoid (MY) CSs are considered more aggressive subtypes due to their metastatic potential and relatively poor outcomes. The aim of this systematic review is to evaluate treatment modalities and survival outcomes in patients affected by these rarer CS subtypes. Methods Papers published from January 1, 2000, to August 25, 2024, describing cases of laryngeal G3, DD, and MY CS were included. Results A total of 38 patients (15 G3, 13 DD, and 10 MY) were selected. Cricoid cartilage was the most common site of origin. Total laryngectomy (TL) was often performed. Primary conservative approaches in 42.8% of patients were followed by loco-regional recurrence. Conclusions Aggressive subtypes of CS require a radical approach because of the higher rate of loco-regional and distant recurrences compared to low-grade CS. TL with radical intent is the most common treatment, and adjuvant therapy should be considered after careful multidisciplinary discussion. |
| format | Article |
| id | doaj-art-403b6425b2f04e92b0e40f61019bfd70 |
| institution | DOAJ |
| issn | 2366-1070 2366-1089 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Oncology and Therapy |
| spelling | doaj-art-403b6425b2f04e92b0e40f61019bfd702025-08-20T03:05:57ZengAdis, Springer HealthcareOncology and Therapy2366-10702366-10892025-01-01131496710.1007/s40487-024-00323-1Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic ReviewCesare Piazza0Claudia Montenegro1Michele Tomasoni2Ilmo Leivo3Göran Stenman4Abbas Agaimy5Roderick H. W. Simpson6Nina Zidar7Alfio Ferlito8Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili of BresciaUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili of BresciaUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili of BresciaInstitute of Biomedicine, Pathology, University of TurkuSahlgrenska Center for Cancer Research, Department of Pathology, University of GothenburgInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-NurnbergDepartment of Anatomical Pathology, University of CalgaryInstitute of Pathology, Faculty of Medicine, University of LjubljanaCoordinator of the International Head and Neck Scientific GroupAbstract Introduction Laryngeal chondrosarcoma (CS) is a rare indolent malignant tumor. High-grade (G3), dedifferentiated (DD), and myxoid (MY) CSs are considered more aggressive subtypes due to their metastatic potential and relatively poor outcomes. The aim of this systematic review is to evaluate treatment modalities and survival outcomes in patients affected by these rarer CS subtypes. Methods Papers published from January 1, 2000, to August 25, 2024, describing cases of laryngeal G3, DD, and MY CS were included. Results A total of 38 patients (15 G3, 13 DD, and 10 MY) were selected. Cricoid cartilage was the most common site of origin. Total laryngectomy (TL) was often performed. Primary conservative approaches in 42.8% of patients were followed by loco-regional recurrence. Conclusions Aggressive subtypes of CS require a radical approach because of the higher rate of loco-regional and distant recurrences compared to low-grade CS. TL with radical intent is the most common treatment, and adjuvant therapy should be considered after careful multidisciplinary discussion.https://doi.org/10.1007/s40487-024-00323-1High gradeDedifferentiatedMyxoidChondrosarcomaLaryngeal tumors |
| spellingShingle | Cesare Piazza Claudia Montenegro Michele Tomasoni Ilmo Leivo Göran Stenman Abbas Agaimy Roderick H. W. Simpson Nina Zidar Alfio Ferlito Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review Oncology and Therapy High grade Dedifferentiated Myxoid Chondrosarcoma Laryngeal tumors |
| title | Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review |
| title_full | Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review |
| title_fullStr | Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review |
| title_full_unstemmed | Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review |
| title_short | Aggressive Subtypes of Laryngeal Chondrosarcoma and their Clinical Behavior: A Systematic Review |
| title_sort | aggressive subtypes of laryngeal chondrosarcoma and their clinical behavior a systematic review |
| topic | High grade Dedifferentiated Myxoid Chondrosarcoma Laryngeal tumors |
| url | https://doi.org/10.1007/s40487-024-00323-1 |
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