Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma
Purpose: To evaluate the serum levels of oxidative stress-related molecules in patients with ocular hypertension (OHT) and primary open-angle glaucoma (POAG) compared with healthy controls. Methods: Treatment-naive patients with no known systemic diseases and with OHT and POAG diagnosis were recru...
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Knowledge E
2024-12-01
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| Series: | Journal of Ophthalmic & Vision Research |
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| Online Access: | https://knepublishing.com/index.php/JOVR/article/view/15011 |
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| author | Mine Esen Baris Onur Furundaoturan Meltem Kocamanoğlu Seray Sahin Yasemin Akçay Suzan Güven Yılmaz |
| author_facet | Mine Esen Baris Onur Furundaoturan Meltem Kocamanoğlu Seray Sahin Yasemin Akçay Suzan Güven Yılmaz |
| author_sort | Mine Esen Baris |
| collection | DOAJ |
| description |
Purpose: To evaluate the serum levels of oxidative stress-related molecules in patients with ocular hypertension (OHT) and primary open-angle glaucoma (POAG) compared with healthy controls.
Methods: Treatment-naive patients with no known systemic diseases and with OHT and POAG diagnosis were recruited for the study. Also, age- and gender-matched healthy volunteers with no ocular and systemic diseases were included as controls. None of the participants were under any topical or systemic treatment or vitamin/antioxidant supplements. Smokers were excluded from the study. Serum levels of total antioxidant capacity (TAC), ascorbic acid, protein carbonyls (PCs), advanced glycation end products (AGEs), neuronal pentraxin 2 (NPTX2), and β-amyloid precursor protein(Aβ) were analyzed.
Results: A total of 90 patients (30 in each group) were included in the study. There was no statistically significant difference between the study groups in terms of age and gender distribution. Serum levels of TAC (1.47 ± 0.11 mmole/L) were significantly higher in patients with OHT compared to controls (1.40 ± 0.11 mmole/L) and patients with POAG (1.30 ± 0.08 mmole/L) (P < 0.05). However, there was no significant difference between the study groups in terms of serum levels of ascorbic acid, PCs, AGEs, NPTX2, and Aβ.
Conclusion: Serum levels of TAC were significantly higher in patients with OHT. This elevated level might contribute to the protection of the optic nerve even in the presence of increased intraocular pressure.
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| format | Article |
| id | doaj-art-40370679740743a8ba9df0947556a706 |
| institution | Kabale University |
| issn | 2008-2010 2008-322X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj-art-40370679740743a8ba9df0947556a7062025-01-21T05:15:07ZengKnowledge EJournal of Ophthalmic & Vision Research2008-20102008-322X2024-12-0119410.18502/jovr.v19i4.15011Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and GlaucomaMine Esen Baris0Onur Furundaoturan1Meltem Kocamanoğlu2Seray Sahin3Yasemin Akçay4Suzan Güven Yılmaz5Ege University Hospital, Department of Ophthalmology, Izmir, TurkeyEge University Hospital, Department of Ophthalmology, Izmir, TurkeyEge University Hospital, Department of Medical Biochemistry, Izmir, TurkeyEge University Hospital, Department of Ophthalmology, Izmir, TurkeyEge University Hospital, Department of Medical Biochemistry, Izmir, TurkeyEge University Hospital, Department of Ophthalmology, Izmir, Turkey Purpose: To evaluate the serum levels of oxidative stress-related molecules in patients with ocular hypertension (OHT) and primary open-angle glaucoma (POAG) compared with healthy controls. Methods: Treatment-naive patients with no known systemic diseases and with OHT and POAG diagnosis were recruited for the study. Also, age- and gender-matched healthy volunteers with no ocular and systemic diseases were included as controls. None of the participants were under any topical or systemic treatment or vitamin/antioxidant supplements. Smokers were excluded from the study. Serum levels of total antioxidant capacity (TAC), ascorbic acid, protein carbonyls (PCs), advanced glycation end products (AGEs), neuronal pentraxin 2 (NPTX2), and β-amyloid precursor protein(Aβ) were analyzed. Results: A total of 90 patients (30 in each group) were included in the study. There was no statistically significant difference between the study groups in terms of age and gender distribution. Serum levels of TAC (1.47 ± 0.11 mmole/L) were significantly higher in patients with OHT compared to controls (1.40 ± 0.11 mmole/L) and patients with POAG (1.30 ± 0.08 mmole/L) (P < 0.05). However, there was no significant difference between the study groups in terms of serum levels of ascorbic acid, PCs, AGEs, NPTX2, and Aβ. Conclusion: Serum levels of TAC were significantly higher in patients with OHT. This elevated level might contribute to the protection of the optic nerve even in the presence of increased intraocular pressure. https://knepublishing.com/index.php/JOVR/article/view/15011HypertensionOcularOpen-angle GlaucomaOxidativeStress |
| spellingShingle | Mine Esen Baris Onur Furundaoturan Meltem Kocamanoğlu Seray Sahin Yasemin Akçay Suzan Güven Yılmaz Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma Journal of Ophthalmic & Vision Research Hypertension Ocular Open-angle Glaucoma Oxidative Stress |
| title | Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma |
| title_full | Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma |
| title_fullStr | Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma |
| title_full_unstemmed | Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma |
| title_short | Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma |
| title_sort | serum oxidative stress related biomarkers in ocular hypertension and glaucoma |
| topic | Hypertension Ocular Open-angle Glaucoma Oxidative Stress |
| url | https://knepublishing.com/index.php/JOVR/article/view/15011 |
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