Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases
Inflammatory bowel diseases (IBDs) are a group of chronic, relapsing, immune-mediated disorders of the intestine, including Crohn's disease and ulcerative colitis. Recent studies underscore the import...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/729172 |
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| _version_ | 1832552632250531840 |
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| author | Anouk Waeytens Martine De Vos Debby Laukens |
| author_facet | Anouk Waeytens Martine De Vos Debby Laukens |
| author_sort | Anouk Waeytens |
| collection | DOAJ |
| description | Inflammatory bowel
diseases (IBDs) are a group of chronic,
relapsing, immune-mediated disorders of the
intestine, including Crohn's disease and
ulcerative colitis. Recent studies underscore
the importance of the damaged epithelial barrier
and the dysregulated innate immune system in
their pathogenesis. Metallothioneins (MTs) are a
family of small proteins with a high and
conserved cysteine content that are rapidly
upregulated in response to an inflammatory
stimulus. Herein, we review the current
knowledge regarding the expression and potential
role of MTs in IBD. MTs exert a central position
in zinc homeostasis, modulate the activation of
the transcription factor nuclear factor
(NF)-𝜅B, and serve as antioxidants. In addition, MTs could be
involved in IBD through their antiapoptotic effects or through
specific immunomodulating extracellular effects. Reports on MT
expression in IBD are contradictory but clearly demonstrate a
deviant MT expression supporting the idea that these aberrations
in IBD require further clarification. |
| format | Article |
| id | doaj-art-403293d2f6de4846b46c618c11858f70 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-403293d2f6de4846b46c618c11858f702025-02-03T05:58:13ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/729172729172Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel DiseasesAnouk Waeytens0Martine De Vos1Debby Laukens2Department of Gastroenterology, Ghent University, De Pintelaan 185, 9000 Gent, BelgiumDepartment of Gastroenterology, Ghent University, De Pintelaan 185, 9000 Gent, BelgiumDepartment of Gastroenterology, Ghent University, De Pintelaan 185, 9000 Gent, BelgiumInflammatory bowel diseases (IBDs) are a group of chronic, relapsing, immune-mediated disorders of the intestine, including Crohn's disease and ulcerative colitis. Recent studies underscore the importance of the damaged epithelial barrier and the dysregulated innate immune system in their pathogenesis. Metallothioneins (MTs) are a family of small proteins with a high and conserved cysteine content that are rapidly upregulated in response to an inflammatory stimulus. Herein, we review the current knowledge regarding the expression and potential role of MTs in IBD. MTs exert a central position in zinc homeostasis, modulate the activation of the transcription factor nuclear factor (NF)-𝜅B, and serve as antioxidants. In addition, MTs could be involved in IBD through their antiapoptotic effects or through specific immunomodulating extracellular effects. Reports on MT expression in IBD are contradictory but clearly demonstrate a deviant MT expression supporting the idea that these aberrations in IBD require further clarification.http://dx.doi.org/10.1155/2009/729172 |
| spellingShingle | Anouk Waeytens Martine De Vos Debby Laukens Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases Mediators of Inflammation |
| title | Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases |
| title_full | Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases |
| title_fullStr | Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases |
| title_full_unstemmed | Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases |
| title_short | Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases |
| title_sort | evidence for a potential role of metallothioneins in inflammatory bowel diseases |
| url | http://dx.doi.org/10.1155/2009/729172 |
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