Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges
As a particularly serious condition in immunocompromised patients, fungal infections (FIs) have increasingly become a public health problem worldwide. Mesenchymal stem cells (MSCs), characterized by multilineage differentiation potential and immunomodulatory properties, are considered an emerging st...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1554917/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582017009582080 |
|---|---|
| author | Yangjie Gao Zhe Ji Jingyu Zhao Julin Gu |
| author_facet | Yangjie Gao Zhe Ji Jingyu Zhao Julin Gu |
| author_sort | Yangjie Gao |
| collection | DOAJ |
| description | As a particularly serious condition in immunocompromised patients, fungal infections (FIs) have increasingly become a public health problem worldwide. Mesenchymal stem cells (MSCs), characterized by multilineage differentiation potential and immunomodulatory properties, are considered an emerging strategy for the treatment of FIs. In this study, the therapeutic potential of MSCs for FIs was reviewed, including their roles played by secreting antimicrobial peptides, regulating immune responses, and promoting tissue repair. Meanwhile, the status of research on MSCs in FIs and the controversies were also discussed. However, the application of MSCs still faces numerous challenges, such as the heterogeneity of cell sources, long-term safety, and feasibility of large-scale production. By analyzing the latest study results, this review intends to offer theoretical support for the application of MSCs in FI treatment and further research. |
| format | Article |
| id | doaj-art-402b9a0436364d85a5cdbcf974ce34df |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-402b9a0436364d85a5cdbcf974ce34df2025-01-30T06:22:30ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011610.3389/fmicb.2025.15549171554917Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challengesYangjie Gao0Zhe Ji1Jingyu Zhao2Julin Gu3Department of Dermatology, Third Affiliated Hospital of Naval Medical University, Shanghai, ChinaDepartment of Pharmacology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Dermatology, Third Affiliated Hospital of Naval Medical University, Shanghai, ChinaDepartment of Dermatology, Third Affiliated Hospital of Naval Medical University, Shanghai, ChinaAs a particularly serious condition in immunocompromised patients, fungal infections (FIs) have increasingly become a public health problem worldwide. Mesenchymal stem cells (MSCs), characterized by multilineage differentiation potential and immunomodulatory properties, are considered an emerging strategy for the treatment of FIs. In this study, the therapeutic potential of MSCs for FIs was reviewed, including their roles played by secreting antimicrobial peptides, regulating immune responses, and promoting tissue repair. Meanwhile, the status of research on MSCs in FIs and the controversies were also discussed. However, the application of MSCs still faces numerous challenges, such as the heterogeneity of cell sources, long-term safety, and feasibility of large-scale production. By analyzing the latest study results, this review intends to offer theoretical support for the application of MSCs in FI treatment and further research.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1554917/fullmesenchymal stem cellsfungal infectionstherapeutic potentialmechanismsapplications |
| spellingShingle | Yangjie Gao Zhe Ji Jingyu Zhao Julin Gu Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges Frontiers in Microbiology mesenchymal stem cells fungal infections therapeutic potential mechanisms applications |
| title | Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges |
| title_full | Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges |
| title_fullStr | Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges |
| title_full_unstemmed | Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges |
| title_short | Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges |
| title_sort | therapeutic potential of mesenchymal stem cells for fungal infections mechanisms applications and challenges |
| topic | mesenchymal stem cells fungal infections therapeutic potential mechanisms applications |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1554917/full |
| work_keys_str_mv | AT yangjiegao therapeuticpotentialofmesenchymalstemcellsforfungalinfectionsmechanismsapplicationsandchallenges AT zheji therapeuticpotentialofmesenchymalstemcellsforfungalinfectionsmechanismsapplicationsandchallenges AT jingyuzhao therapeuticpotentialofmesenchymalstemcellsforfungalinfectionsmechanismsapplicationsandchallenges AT julingu therapeuticpotentialofmesenchymalstemcellsforfungalinfectionsmechanismsapplicationsandchallenges |