Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation
The potent suppression of adipocyte differentiation by 4-(4-methylbenzamino)benzoate was discovered during the search for new antiobesity compounds. 4-(4-methylbenzamino)benzoate was observed to suppress adipocyte differentiation in 3T3-L1 cells by 96.8% at 50 μM without cytotoxicity. In addition, 4...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/171570 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561698151596032 |
|---|---|
| author | Jin Taek Hwang Sanghee Kim Bo-ra Yoon Inwook Choi Sang Yoon Choi |
| author_facet | Jin Taek Hwang Sanghee Kim Bo-ra Yoon Inwook Choi Sang Yoon Choi |
| author_sort | Jin Taek Hwang |
| collection | DOAJ |
| description | The potent suppression of adipocyte differentiation by 4-(4-methylbenzamino)benzoate was discovered during the search for new antiobesity compounds. 4-(4-methylbenzamino)benzoate was observed to suppress adipocyte differentiation in 3T3-L1 cells by 96.8% at 50 μM without cytotoxicity. In addition, 4-(4-methylbenzamino)benzoate reduced the cellular expression of fatty acid synthase in a concentration-dependent manner, as well as suppressing PPAR-gamma activity, which controls fatty acid storage and glucose metabolism. Based on these results, 4-(4-methylbenzamino)benzoate shows potential as an antiobesity material. |
| format | Article |
| id | doaj-art-402b5405625541e1a14ae04cfe06bbb9 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-402b5405625541e1a14ae04cfe06bbb92025-02-03T01:24:27ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/171570171570Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte DifferentiationJin Taek Hwang0Sanghee Kim1Bo-ra Yoon2Inwook Choi3Sang Yoon Choi4Korea Food Research Institute, Seongnam 463-746, Republic of KoreaCollege of Pharmacy, Seoul National University, Seoul 151-742, Republic of KoreaKorea Food Research Institute, Seongnam 463-746, Republic of KoreaKorea Food Research Institute, Seongnam 463-746, Republic of KoreaKorea Food Research Institute, Seongnam 463-746, Republic of KoreaThe potent suppression of adipocyte differentiation by 4-(4-methylbenzamino)benzoate was discovered during the search for new antiobesity compounds. 4-(4-methylbenzamino)benzoate was observed to suppress adipocyte differentiation in 3T3-L1 cells by 96.8% at 50 μM without cytotoxicity. In addition, 4-(4-methylbenzamino)benzoate reduced the cellular expression of fatty acid synthase in a concentration-dependent manner, as well as suppressing PPAR-gamma activity, which controls fatty acid storage and glucose metabolism. Based on these results, 4-(4-methylbenzamino)benzoate shows potential as an antiobesity material.http://dx.doi.org/10.1155/2015/171570 |
| spellingShingle | Jin Taek Hwang Sanghee Kim Bo-ra Yoon Inwook Choi Sang Yoon Choi Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation Journal of Chemistry |
| title | Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation |
| title_full | Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation |
| title_fullStr | Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation |
| title_full_unstemmed | Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation |
| title_short | Inhibitory Effects of 4-(4-Methylbenzamino)benzoate on Adipocyte Differentiation |
| title_sort | inhibitory effects of 4 4 methylbenzamino benzoate on adipocyte differentiation |
| url | http://dx.doi.org/10.1155/2015/171570 |
| work_keys_str_mv | AT jintaekhwang inhibitoryeffectsof44methylbenzaminobenzoateonadipocytedifferentiation AT sangheekim inhibitoryeffectsof44methylbenzaminobenzoateonadipocytedifferentiation AT borayoon inhibitoryeffectsof44methylbenzaminobenzoateonadipocytedifferentiation AT inwookchoi inhibitoryeffectsof44methylbenzaminobenzoateonadipocytedifferentiation AT sangyoonchoi inhibitoryeffectsof44methylbenzaminobenzoateonadipocytedifferentiation |