Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-α and blood-brain barrier damage
The mechanism for the initiation of blood-brain barrier damage and intrathecal inflammation in patients infected with the human immunodeficiency virus (HIV) is poorly understood. We have recently reported that tumour necrosis factor-α (TNF-α) mediates active neural inflammation and blood-brain barri...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000486 |
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| author | M. K. Sharief M. Ciardi M. A. Noori E. J. Thompson A. Salotti F. Sorice F. Rossi A. Cirelli |
| author_facet | M. K. Sharief M. Ciardi M. A. Noori E. J. Thompson A. Salotti F. Sorice F. Rossi A. Cirelli |
| author_sort | M. K. Sharief |
| collection | DOAJ |
| description | The mechanism for the initiation of blood-brain barrier damage and intrathecal inflammation in patients infected with the human immunodeficiency virus (HIV) is poorly understood. We have recently reported that tumour necrosis factor-α (TNF-α) mediates active neural inflammation and blood-brain barrier damage in HIV-1 infection. Stimulation of endothelial cells by TNF-α induces the expression of intercellular adhesion molecule-1 (ICAM-1), which is an important early marker of immune activation and response. We report herein for the first time the detection of high levels of free circulating ICAM-1 in serum and cerebrospinal fluid of patients with HIV-1 infection. Free circulating ICAM-1 in these patients correlated with TNF-α concentrations and with the degree of blood-brain barrier damage and were detected predominantly in patients with neurologic involvement. These findings have important implications for the understanding and investigation of the intrathecal inflammatory response in HIV-1 infection. |
| format | Article |
| id | doaj-art-402a675cf7144a9986d78708d66e700c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-402a675cf7144a9986d78708d66e700c2025-02-03T06:07:13ZengWileyMediators of Inflammation0962-93511466-18611992-01-011532332810.1155/S0962935192000486Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-α and blood-brain barrier damageM. K. Sharief0M. Ciardi1M. A. Noori2E. J. Thompson3A. Salotti4F. Sorice5F. Rossi6A. Cirelli7Department of Neurochemistry, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UKDepartment of Neurochemistry, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UKThe Royal London Hospital, Whitechapel, London, UKDepartment of Neurochemistry, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UKInstitute of Infectious Diseases, University of Rome “La Sapienza”, Rome 00161, ItalyInstitute of Infectious Diseases, University of Rome “La Sapienza”, Rome 00161, ItalyInstitute of Infectious Diseases, University of Rome “La Sapienza”, Rome 00161, ItalyDepartment of Infectious Diseases, University of Pisa, Pisa 2013, ItalyThe mechanism for the initiation of blood-brain barrier damage and intrathecal inflammation in patients infected with the human immunodeficiency virus (HIV) is poorly understood. We have recently reported that tumour necrosis factor-α (TNF-α) mediates active neural inflammation and blood-brain barrier damage in HIV-1 infection. Stimulation of endothelial cells by TNF-α induces the expression of intercellular adhesion molecule-1 (ICAM-1), which is an important early marker of immune activation and response. We report herein for the first time the detection of high levels of free circulating ICAM-1 in serum and cerebrospinal fluid of patients with HIV-1 infection. Free circulating ICAM-1 in these patients correlated with TNF-α concentrations and with the degree of blood-brain barrier damage and were detected predominantly in patients with neurologic involvement. These findings have important implications for the understanding and investigation of the intrathecal inflammatory response in HIV-1 infection.http://dx.doi.org/10.1155/S0962935192000486 |
| spellingShingle | M. K. Sharief M. Ciardi M. A. Noori E. J. Thompson A. Salotti F. Sorice F. Rossi A. Cirelli Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-α and blood-brain barrier damage Mediators of Inflammation |
| title | Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-α and blood-brain barrier damage |
| title_full | Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-α and blood-brain barrier damage |
| title_fullStr | Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-α and blood-brain barrier damage |
| title_full_unstemmed | Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-α and blood-brain barrier damage |
| title_short | Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-α and blood-brain barrier damage |
| title_sort | free circulating icam 1 in serum and cerebrospinal fluid of hiv 1 infected patients correlate with tnf α and blood brain barrier damage |
| url | http://dx.doi.org/10.1155/S0962935192000486 |
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