Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational Research
Translational research in preterm brain injury depends upon the delineation of the human neuropathology in order that animal models faithfully reiterate it, thereby ensuring direct relevance to the human condition. The major substrate of human preterm brain injury is the encephalopathy of prematurit...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/295389 |
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| author | Hannah C. Kinney Joseph J. Volpe |
| author_facet | Hannah C. Kinney Joseph J. Volpe |
| author_sort | Hannah C. Kinney |
| collection | DOAJ |
| description | Translational research in preterm brain injury depends upon the delineation of the human neuropathology in order that animal models faithfully reiterate it, thereby ensuring direct relevance to the human condition. The major substrate of human preterm brain injury is the encephalopathy of prematurity that is characterized by gray and white matter lesions reflecting combined acquired insults, altered developmental trajectories, and reparative phenomena. Here we highlight the key features of human preterm brain development and the encephalopathy of prematurity that are critical for modeling in animals. The complete mimicry of the complex human neuropathology is difficult in animal models. Many models focus upon mechanisms related to a specific feature, for example, loss of premyelinating oligodendrocytes in the cerebral white matter. Nevertheless, animal models that simultaneously address oligodendrocyte, neuronal, and axonal injury carry the potential to decipher shared mechanisms and synergistic treatments to ameliorate the global consequences of the encephalopathy of prematurity. |
| format | Article |
| id | doaj-art-40287394d33d4582ab2909b1f0b006b2 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-40287394d33d4582ab2909b1f0b006b22025-02-03T05:50:43ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/295389295389Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational ResearchHannah C. Kinney0Joseph J. Volpe1Department of Pathology, Children’s Hospital Boston and Harvard Medical School, Boston, MA 02115, USADepartment of Neurology, Children’s Hospital Boston and Harvard Medical School, Boston, MA 02115, USATranslational research in preterm brain injury depends upon the delineation of the human neuropathology in order that animal models faithfully reiterate it, thereby ensuring direct relevance to the human condition. The major substrate of human preterm brain injury is the encephalopathy of prematurity that is characterized by gray and white matter lesions reflecting combined acquired insults, altered developmental trajectories, and reparative phenomena. Here we highlight the key features of human preterm brain development and the encephalopathy of prematurity that are critical for modeling in animals. The complete mimicry of the complex human neuropathology is difficult in animal models. Many models focus upon mechanisms related to a specific feature, for example, loss of premyelinating oligodendrocytes in the cerebral white matter. Nevertheless, animal models that simultaneously address oligodendrocyte, neuronal, and axonal injury carry the potential to decipher shared mechanisms and synergistic treatments to ameliorate the global consequences of the encephalopathy of prematurity.http://dx.doi.org/10.1155/2012/295389 |
| spellingShingle | Hannah C. Kinney Joseph J. Volpe Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational Research Neurology Research International |
| title | Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational Research |
| title_full | Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational Research |
| title_fullStr | Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational Research |
| title_full_unstemmed | Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational Research |
| title_short | Modeling the Encephalopathy of Prematurity in Animals: The Important Role of Translational Research |
| title_sort | modeling the encephalopathy of prematurity in animals the important role of translational research |
| url | http://dx.doi.org/10.1155/2012/295389 |
| work_keys_str_mv | AT hannahckinney modelingtheencephalopathyofprematurityinanimalstheimportantroleoftranslationalresearch AT josephjvolpe modelingtheencephalopathyofprematurityinanimalstheimportantroleoftranslationalresearch |