Immune Response in H. pylori-Associated Gastritis and Gastric Cancer
Helicobacter pylori (H. pylori) is the dominant member of the gastric microbiota and has infected more than half of the human population, of whom 5–15% develop gastric diseases ranging from gastritis and metaplasia to gastric cancer. These diseases always follow inflammation induced by cell surface...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/9342563 |
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| author | Qingbin Niu Jun Zhu Xingquan Yu Tao Feng Hong Ji Yuming Li Weiwei Zhang Baoguang Hu |
| author_facet | Qingbin Niu Jun Zhu Xingquan Yu Tao Feng Hong Ji Yuming Li Weiwei Zhang Baoguang Hu |
| author_sort | Qingbin Niu |
| collection | DOAJ |
| description | Helicobacter pylori (H. pylori) is the dominant member of the gastric microbiota and has infected more than half of the human population, of whom 5–15% develop gastric diseases ranging from gastritis and metaplasia to gastric cancer. These diseases always follow inflammation induced by cell surface and intracellular receptors and subsequent signaling, such as the NF-κB pathway and inflammasomes. Some types of immune cells are recruited to enforce an antibacterial response, which could be impeded by H. pylori virulence factors with or without a specific immune cell. Following decreased inflammation, neoplasm may appear with a little immune surveillance and may inhibit antitumor immunity. Therefore, the balance between H. pylori-associated inflammation and anti-inflammation is crucial for human health and remains to be determined. Here, we discuss multiple inflammation and immunoregulatory cells in gastritis and summarize the main immune evasion strategies employed by gastric cancer. |
| format | Article |
| id | doaj-art-40253899205847dc830827aec7f7db2d |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-40253899205847dc830827aec7f7db2d2025-02-03T01:05:23ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/93425639342563Immune Response in H. pylori-Associated Gastritis and Gastric CancerQingbin Niu0Jun Zhu1Xingquan Yu2Tao Feng3Hong Ji4Yuming Li5Weiwei Zhang6Baoguang Hu7Department of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Pathology, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Anesthesiology, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaHelicobacter pylori (H. pylori) is the dominant member of the gastric microbiota and has infected more than half of the human population, of whom 5–15% develop gastric diseases ranging from gastritis and metaplasia to gastric cancer. These diseases always follow inflammation induced by cell surface and intracellular receptors and subsequent signaling, such as the NF-κB pathway and inflammasomes. Some types of immune cells are recruited to enforce an antibacterial response, which could be impeded by H. pylori virulence factors with or without a specific immune cell. Following decreased inflammation, neoplasm may appear with a little immune surveillance and may inhibit antitumor immunity. Therefore, the balance between H. pylori-associated inflammation and anti-inflammation is crucial for human health and remains to be determined. Here, we discuss multiple inflammation and immunoregulatory cells in gastritis and summarize the main immune evasion strategies employed by gastric cancer.http://dx.doi.org/10.1155/2020/9342563 |
| spellingShingle | Qingbin Niu Jun Zhu Xingquan Yu Tao Feng Hong Ji Yuming Li Weiwei Zhang Baoguang Hu Immune Response in H. pylori-Associated Gastritis and Gastric Cancer Gastroenterology Research and Practice |
| title | Immune Response in H. pylori-Associated Gastritis and Gastric Cancer |
| title_full | Immune Response in H. pylori-Associated Gastritis and Gastric Cancer |
| title_fullStr | Immune Response in H. pylori-Associated Gastritis and Gastric Cancer |
| title_full_unstemmed | Immune Response in H. pylori-Associated Gastritis and Gastric Cancer |
| title_short | Immune Response in H. pylori-Associated Gastritis and Gastric Cancer |
| title_sort | immune response in h pylori associated gastritis and gastric cancer |
| url | http://dx.doi.org/10.1155/2020/9342563 |
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