Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease
Ubiquitination is a three-step enzymatic cascade for posttranslational protein modification. It includes the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin ligase (E3). RING-type E3 ubiquitin ligases catalyse the posttranslational proteolytic and nonproteolytic fu...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/5310180 |
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| _version_ | 1832546866099650560 |
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| author | Liguo Zhu Ying Li Longyuan Zhou Guang Yang Ying Wang Jing Han Li Li Shenghong Zhang |
| author_facet | Liguo Zhu Ying Li Longyuan Zhou Guang Yang Ying Wang Jing Han Li Li Shenghong Zhang |
| author_sort | Liguo Zhu |
| collection | DOAJ |
| description | Ubiquitination is a three-step enzymatic cascade for posttranslational protein modification. It includes the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin ligase (E3). RING-type E3 ubiquitin ligases catalyse the posttranslational proteolytic and nonproteolytic functions in various physiological and pathological processes, such as inflammation-associated signal transduction. Resulting from the diversity of substrates and functional mechanisms, RING-type ligases regulate microbe recognition and inflammation by being involved in multiple inflammatory signalling pathways. These processes also occur in autoimmune diseases, especially inflammatory bowel disease (IBD). To understand the importance of RING-type ligases in inflammation, we have discussed their functional mechanisms in multiple inflammation-associated pathways and correlation between RING-type ligases and IBD. Owing to the limited data on the biology of RING-type ligases, there is an urgent need to analyse their potential as biomarkers and therapeutic targets in IBD in the future. |
| format | Article |
| id | doaj-art-402044c5c22949859b9f2280ec57c67f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-402044c5c22949859b9f2280ec57c67f2025-02-03T06:46:51ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/53101805310180Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel DiseaseLiguo Zhu0Ying Li1Longyuan Zhou2Guang Yang3Ying Wang4Jing Han5Li Li6Shenghong Zhang7Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDivision of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaUbiquitination is a three-step enzymatic cascade for posttranslational protein modification. It includes the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin ligase (E3). RING-type E3 ubiquitin ligases catalyse the posttranslational proteolytic and nonproteolytic functions in various physiological and pathological processes, such as inflammation-associated signal transduction. Resulting from the diversity of substrates and functional mechanisms, RING-type ligases regulate microbe recognition and inflammation by being involved in multiple inflammatory signalling pathways. These processes also occur in autoimmune diseases, especially inflammatory bowel disease (IBD). To understand the importance of RING-type ligases in inflammation, we have discussed their functional mechanisms in multiple inflammation-associated pathways and correlation between RING-type ligases and IBD. Owing to the limited data on the biology of RING-type ligases, there is an urgent need to analyse their potential as biomarkers and therapeutic targets in IBD in the future.http://dx.doi.org/10.1155/2020/5310180 |
| spellingShingle | Liguo Zhu Ying Li Longyuan Zhou Guang Yang Ying Wang Jing Han Li Li Shenghong Zhang Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease Mediators of Inflammation |
| title | Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease |
| title_full | Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease |
| title_fullStr | Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease |
| title_full_unstemmed | Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease |
| title_short | Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease |
| title_sort | role of ring type e3 ubiquitin ligases in inflammatory signalling and inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2020/5310180 |
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