Pathophysiology of Vascular Remodeling in Hypertension
Vascular remodeling refers to alterations in the structure of resistance vessels contributing to elevated systemic vascular resistance in hypertension. We start with some historical aspects, underscoring the importance of Glagov’s contribution. We then move to some basic concepts on the biomechanics...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2013/808353 |
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| author | Nicolás F. Renna Natalia de las Heras Roberto M. Miatello |
| author_facet | Nicolás F. Renna Natalia de las Heras Roberto M. Miatello |
| author_sort | Nicolás F. Renna |
| collection | DOAJ |
| description | Vascular remodeling refers to alterations in the structure of resistance vessels contributing to elevated systemic vascular resistance in hypertension. We start with some historical aspects, underscoring the importance of Glagov’s contribution. We then move to some basic concepts on the biomechanics of blood vessels and explain the definitions proposed by Mulvany for specific forms of remodeling, especially inward eutrophic and inward hypertrophic. The available evidence for the existence of remodeled resistance vessels in hypertension comes next, with relatively more weight given to human, in comparison with animal data. Mechanisms are discussed. The impact of antihypertensive drug treatment on remodeling is described, again with emphasis on human data. Some details are given on the three mechanisms to date which point to remodeling resistance arteries as an independent predictor of cardiovascular risk in hypertensive patients. We terminate by considering the potential role of remodeling in the pathogenesis of endorgan damage and in the perpetuation of hypertension. |
| format | Article |
| id | doaj-art-401c33f9bffe41b7a04dbd5da1ad512c |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-401c33f9bffe41b7a04dbd5da1ad512c2025-02-03T01:25:34ZengWileyInternational Journal of Hypertension2090-03842090-03922013-01-01201310.1155/2013/808353808353Pathophysiology of Vascular Remodeling in HypertensionNicolás F. Renna0Natalia de las Heras1Roberto M. Miatello2Department of Pathology, School of Medicine, National University of Cuyo, Avenida Libertador 80, Centro Universitario, 5500 Mendoza, ArgentinaDepartment of Physiology, School of Medicine, Universidad Complutense, Plaza de Ramón y Cajal s.n., 28040 Madrid, SpainDepartment of Pathology, School of Medicine, National University of Cuyo, Avenida Libertador 80, Centro Universitario, 5500 Mendoza, ArgentinaVascular remodeling refers to alterations in the structure of resistance vessels contributing to elevated systemic vascular resistance in hypertension. We start with some historical aspects, underscoring the importance of Glagov’s contribution. We then move to some basic concepts on the biomechanics of blood vessels and explain the definitions proposed by Mulvany for specific forms of remodeling, especially inward eutrophic and inward hypertrophic. The available evidence for the existence of remodeled resistance vessels in hypertension comes next, with relatively more weight given to human, in comparison with animal data. Mechanisms are discussed. The impact of antihypertensive drug treatment on remodeling is described, again with emphasis on human data. Some details are given on the three mechanisms to date which point to remodeling resistance arteries as an independent predictor of cardiovascular risk in hypertensive patients. We terminate by considering the potential role of remodeling in the pathogenesis of endorgan damage and in the perpetuation of hypertension.http://dx.doi.org/10.1155/2013/808353 |
| spellingShingle | Nicolás F. Renna Natalia de las Heras Roberto M. Miatello Pathophysiology of Vascular Remodeling in Hypertension International Journal of Hypertension |
| title | Pathophysiology of Vascular Remodeling in Hypertension |
| title_full | Pathophysiology of Vascular Remodeling in Hypertension |
| title_fullStr | Pathophysiology of Vascular Remodeling in Hypertension |
| title_full_unstemmed | Pathophysiology of Vascular Remodeling in Hypertension |
| title_short | Pathophysiology of Vascular Remodeling in Hypertension |
| title_sort | pathophysiology of vascular remodeling in hypertension |
| url | http://dx.doi.org/10.1155/2013/808353 |
| work_keys_str_mv | AT nicolasfrenna pathophysiologyofvascularremodelinginhypertension AT nataliadelasheras pathophysiologyofvascularremodelinginhypertension AT robertommiatello pathophysiologyofvascularremodelinginhypertension |