Efficacy of a Food Supplement Based on Collagen and Magnesium Combined with Pelvic Floor Muscle Training Exercises in Women with Urinary Incontinence: A Double-Blind, Randomized, Pilot Clinical Trial
Background/Objectives: Urinary incontinence (UI) is a common condition affecting women worldwide, with pelvic floor muscle training exercises (PFMT) recognized as the first-line treatment for UI. Supplementation with bioactive compounds, such as collagen and magnesium, may enhance the effectiveness...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Uro |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4397/5/2/7 |
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| Summary: | Background/Objectives: Urinary incontinence (UI) is a common condition affecting women worldwide, with pelvic floor muscle training exercises (PFMT) recognized as the first-line treatment for UI. Supplementation with bioactive compounds, such as collagen and magnesium, may enhance the effectiveness of PFMT. This study aimed to evaluate the efficacy of combining a food supplement containing collagen and magnesium with PFMT in women experiencing stress (SUI), urge (UUI), or mixed (MUI) urinary incontinence. Methods: A pilot clinical trial was carried out on 44 women with stress, urge, or mixed urinary incontinence. The improvement in urinary incontinence was assessed, before and after 6 weeks (W6) of product use, by the Questionnaire for Urinary Incontinence Diagnosis (QUID) and the clinical assessment of the gynecologist. Quality of life (QoL) was assessed as a secondary endpoint. Results: At Week 6, the baseline median QUID score in the active group was significantly reduced by 64% (<i>p</i> < 0.001), with 76% finishing the study with a negative diagnosis for UI. In contrast, the placebo group showed a reduction in QUID score by only 10% (<i>p</i> < 0.001), with just 25% of participants achieving a negative diagnosis for UI. QoL statistically significantly (<i>p</i> < 0.001) improved by 76% in the active group, while no changes were observed in the placebo group. Conclusions: Supplementation with the (Dermoxen<sup>®</sup> PelviPlus™/Dermoxen<sup>®</sup> Gynable<sup>®</sup> Urocollagen™) tested product significantly improved urinary symptoms and quality of life, demonstrating a greater effect than pelvic floor muscle training (PFMT) exercises alone. Dermoxen<sup>®</sup> PelviPlus™/Dermoxen<sup>®</sup> Gynable<sup>®</sup> Urocollagen™ demonstrated efficacy across all three subtypes of UI. |
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| ISSN: | 2673-4397 |