Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in context
Summary: Background: Assessing the burden of antimicrobial resistance is essential to determine the magnitude of this problem and to set its priority. We aimed to estimate the burden of disease caused by multidrug-resistant microorganisms (MDRO) in hospitalised patients in Spain. Methods: Three pro...
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2025-04-01
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| author | Germán Peñalva Rafael Cantón María Teresa Pérez-Rodríguez Juan José González-López Jesús Rodríguez-Baño Ester del Barrio-Tofiño Cristina Kirkegaard-Biosca Isabel Sánchez-Romero Andrea Gutiérrez-Villanueva Teresa Marrodán-Ciordia José Manuel Guerra-Laso Cristóbal del Rosario-Quintana Laura Suárez-Hormiga Jordi Cámara Mireia Puig-Asensio Eva Heredero María Antonia Sepúlveda Juan Carlos Rodríguez-Díaz Esperanza Merino Emilia Cercenado Sofia de la Villa María Siller Francisco Arnaiz Cristina Seral José Antonio Lepe José Miguel Cisneros José Ramón Paño-Pardo |
| author_facet | Germán Peñalva Rafael Cantón María Teresa Pérez-Rodríguez Juan José González-López Jesús Rodríguez-Baño Ester del Barrio-Tofiño Cristina Kirkegaard-Biosca Isabel Sánchez-Romero Andrea Gutiérrez-Villanueva Teresa Marrodán-Ciordia José Manuel Guerra-Laso Cristóbal del Rosario-Quintana Laura Suárez-Hormiga Jordi Cámara Mireia Puig-Asensio Eva Heredero María Antonia Sepúlveda Juan Carlos Rodríguez-Díaz Esperanza Merino Emilia Cercenado Sofia de la Villa María Siller Francisco Arnaiz Cristina Seral José Antonio Lepe José Miguel Cisneros José Ramón Paño-Pardo |
| author_sort | Germán Peñalva |
| collection | DOAJ |
| description | Summary: Background: Assessing the burden of antimicrobial resistance is essential to determine the magnitude of this problem and to set its priority. We aimed to estimate the burden of disease caused by multidrug-resistant microorganisms (MDRO) in hospitalised patients in Spain. Methods: Three prospective nationwide studies were conducted in 2018, 2019 and 2023. All patients with a new diagnosis of infection with any of 10 selected MDROs plus Clostridioides difficile during the study period (one week in 2018 and 2019 and two weeks in 2023) were included. Patient demographic, and clinical outcomes were analysed, including incidence, crude all-cause 30-day mortality and years of life lost (YLL). These results were used to calculate weighted and seasonally adjusted annual estimates for the whole country. Findings: In total, 82, 133 and 130 centres participated in the study in 2018, 2019 and 2023, respectively, recording a total of 907, 1392 and 2351 MDRO infections, representing a weighted incidence density of 3.54 (95% CI 2.92–4.17), 5.01 (3.95–6.07), and 4.41 (3.55–5.27) cases/1000 stays, respectively. A total of 161, 198 and 352 patients died with an MDRO infection, representing a weighted incidence density of 0.46 (0.16–0.76), 0.43 (0.17–0.69), and 0.62 (0.52–0.72) deaths/1000 stays, respectively. Based on these data, a nationwide occurrence of 155,294 MDRO infections (95% CI 127,928–182,569) with 20,065 deaths (6938–32,958) was estimated for 2018, 210,451 MDRO infections (165,963–254,975) with 17,982 deaths (7071–28,700) for 2019, and 173,653 MDRO infections (139,814–207258) with 24,582 deaths (20,461–28,796) for 2023. Interpretation: The burden of disease caused by MDRO infections among hospitalised patients in Spain is very high and remains stable over the study period. National actions to combat bacterial resistance need to be intensified. Funding: The management costs of this study were funded by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC). Researchers have participated voluntarily and none of the investigators received funding for conducting the study. |
| format | Article |
| id | doaj-art-3fdef49020c94ae49c1aa095f9743a07 |
| institution | Kabale University |
| issn | 2666-7762 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
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| series | The Lancet Regional Health. Europe |
| spelling | doaj-art-3fdef49020c94ae49c1aa095f9743a072025-01-31T05:12:32ZengElsevierThe Lancet Regional Health. Europe2666-77622025-04-0151101220Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in contextGermán Peñalva0Rafael Cantón1María Teresa Pérez-Rodríguez2Juan José González-López3Jesús Rodríguez-Baño4Ester del Barrio-Tofiño5Cristina Kirkegaard-Biosca6Isabel Sánchez-Romero7Andrea Gutiérrez-Villanueva8Teresa Marrodán-Ciordia9José Manuel Guerra-Laso10Cristóbal del Rosario-Quintana11Laura Suárez-Hormiga12Jordi Cámara13Mireia Puig-Asensio14Eva Heredero15María Antonia Sepúlveda16Juan Carlos Rodríguez-Díaz17Esperanza Merino18Emilia Cercenado19Sofia de la Villa20María Siller21Francisco Arnaiz22Cristina Seral23José Antonio Lepe24José Miguel Cisneros25José Ramón Paño-Pardo26Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain; Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, SpainHospital Álvaro Cunqueiro, Instituto de Investigación Sanitaria Galicia Sur (IIS Galicia Sur), Vigo (Pontevedra), Spain; Healthcare Associated Infections Study Group (GEIRAS), Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC), Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain; Hospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain; Antimicrobial Resistance and Mechanisms of Action Study Group (GEMARA), Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC), Madrid, SpainCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain; Institute of Biomedicine of Seville (IBiS), University Hospital Virgen Macarena, CSIC/Universidad de Sevilla, Departamento de Medicina, Universidad de Sevilla, Seville, SpainHospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, SpainHospital Universitari Vall d’Hebron, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, SpainInstituto de Investigación Sanitaria Puerta de Hierro – Segovia de Arana, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainInstituto de Investigación Sanitaria Puerta de Hierro – Segovia de Arana, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainComplejo Asistencial Universitario de León, León, SpainComplejo Asistencial Universitario de León, León, SpainHospital Universitario Insular de Gran Canaria, Las Palmas, SpainHospital Universitario Insular de Gran Canaria, Las Palmas, SpainHospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, SpainHospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, SpainComplejo Hospitalario Universitario de Toledo, Toledo, SpainComplejo Hospitalario Universitario de Toledo, Toledo, SpainHospital General Universitario Dr. Balmis, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, SpainHospital General Universitario Dr. Balmis, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, SpainHospital Universitario Gregorio Marañón, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, SpainHospital Universitario Gregorio Marañón, Madrid, SpainHospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, SpainHospital Universitario Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, Santander, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, SpainInstituto de Investigación Sanitaria Aragón (IIS Aragón), Hospital Clínico Universitario, Universidad de Zaragoza, Zaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, SpainInstitute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, SpainInstitute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain; Corresponding author. Department of Infectious Diseases, Microbiology and Parasitology, Virgen del Rocío University Hospital, University of Seville, Institute of Biomedicine of Seville, Av. Manuel Siurot, s/n, 41013, Seville, Spain.Instituto de Investigación Sanitaria Aragón (IIS Aragón), Hospital Clínico Universitario, Universidad de Zaragoza, Zaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, SpainSummary: Background: Assessing the burden of antimicrobial resistance is essential to determine the magnitude of this problem and to set its priority. We aimed to estimate the burden of disease caused by multidrug-resistant microorganisms (MDRO) in hospitalised patients in Spain. Methods: Three prospective nationwide studies were conducted in 2018, 2019 and 2023. All patients with a new diagnosis of infection with any of 10 selected MDROs plus Clostridioides difficile during the study period (one week in 2018 and 2019 and two weeks in 2023) were included. Patient demographic, and clinical outcomes were analysed, including incidence, crude all-cause 30-day mortality and years of life lost (YLL). These results were used to calculate weighted and seasonally adjusted annual estimates for the whole country. Findings: In total, 82, 133 and 130 centres participated in the study in 2018, 2019 and 2023, respectively, recording a total of 907, 1392 and 2351 MDRO infections, representing a weighted incidence density of 3.54 (95% CI 2.92–4.17), 5.01 (3.95–6.07), and 4.41 (3.55–5.27) cases/1000 stays, respectively. A total of 161, 198 and 352 patients died with an MDRO infection, representing a weighted incidence density of 0.46 (0.16–0.76), 0.43 (0.17–0.69), and 0.62 (0.52–0.72) deaths/1000 stays, respectively. Based on these data, a nationwide occurrence of 155,294 MDRO infections (95% CI 127,928–182,569) with 20,065 deaths (6938–32,958) was estimated for 2018, 210,451 MDRO infections (165,963–254,975) with 17,982 deaths (7071–28,700) for 2019, and 173,653 MDRO infections (139,814–207258) with 24,582 deaths (20,461–28,796) for 2023. Interpretation: The burden of disease caused by MDRO infections among hospitalised patients in Spain is very high and remains stable over the study period. National actions to combat bacterial resistance need to be intensified. Funding: The management costs of this study were funded by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC). Researchers have participated voluntarily and none of the investigators received funding for conducting the study.http://www.sciencedirect.com/science/article/pii/S2666776225000122Antimicrobial resistanceInfectionsBurdenHospitalSpain |
| spellingShingle | Germán Peñalva Rafael Cantón María Teresa Pérez-Rodríguez Juan José González-López Jesús Rodríguez-Baño Ester del Barrio-Tofiño Cristina Kirkegaard-Biosca Isabel Sánchez-Romero Andrea Gutiérrez-Villanueva Teresa Marrodán-Ciordia José Manuel Guerra-Laso Cristóbal del Rosario-Quintana Laura Suárez-Hormiga Jordi Cámara Mireia Puig-Asensio Eva Heredero María Antonia Sepúlveda Juan Carlos Rodríguez-Díaz Esperanza Merino Emilia Cercenado Sofia de la Villa María Siller Francisco Arnaiz Cristina Seral José Antonio Lepe José Miguel Cisneros José Ramón Paño-Pardo Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in context The Lancet Regional Health. Europe Antimicrobial resistance Infections Burden Hospital Spain |
| title | Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in context |
| title_full | Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in context |
| title_fullStr | Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in context |
| title_full_unstemmed | Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in context |
| title_short | Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studiesResearch in context |
| title_sort | burden of bacterial antimicrobial resistance among hospitalised patients in spain findings from three nationwide prospective studiesresearch in context |
| topic | Antimicrobial resistance Infections Burden Hospital Spain |
| url | http://www.sciencedirect.com/science/article/pii/S2666776225000122 |
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