Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study
Introduction. Left ventricular dysfunction is quite common in septic shock. Speckle-tracking echocardiography (STE) is a novel, highly sensitive method for assessing left ventricular function, capable of detecting subclinical myocardial dysfunction, which is not identified with conventional echocard...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/6098654 |
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| author | Pham Dang Hai Le Lan Phuong Nguyen Manh Dung Le Thi Viet Hoa Do Van Quyen Nguyen Xuan Chinh Vu Duy Minh Pham Nguyen Son |
| author_facet | Pham Dang Hai Le Lan Phuong Nguyen Manh Dung Le Thi Viet Hoa Do Van Quyen Nguyen Xuan Chinh Vu Duy Minh Pham Nguyen Son |
| author_sort | Pham Dang Hai |
| collection | DOAJ |
| description | Introduction. Left ventricular dysfunction is quite common in septic shock. Speckle-tracking echocardiography (STE) is a novel, highly sensitive method for assessing left ventricular function, capable of detecting subclinical myocardial dysfunction, which is not identified with conventional echocardiography. We sought to evaluate subclinical left ventricular systolic function in patients with septic shock using speckle-tracking echocardiography. Methods. From May 2017 to December 2018, patients aged ≥18 years admitted to the intensive care unit with the diagnosis of sepsis and septic shock based on the sepsis-3 definition were included. Patients with other causes of cardiac dysfunction were excluded. Transthoracic echocardiography was performed for all the patients within 24 hours of diagnosis. Left ventricular systolic function was assessed using conventional echocardiography and speckle-tracking echocardiography. Results. Patients with septic shock (n = 90) (study group) and 37 matched patients with sepsis but no septic shock (control group) were included. Left ventricular ejection fraction (LVEF) by conventional echocardiography showed no significant difference between two groups (58.2 ± 9.9 vs. 58.6 ± 8.3, p=0.804). The global longitudinal strain (GLS) by STE was significantly reduced in patients with septic shock compared with that in the control (−14.6 ± 3.3 vs. −17.1 ± 3.3, p<0.001). Based on the cutoff value of GLS ≥ −15% for the definition of subclinical left ventricular systolic dysfunction, this dysfunction was detected in 50 patients with septic shock (55.6%) and in 6 patients in the control group (16.2%) (p<0.05). Conclusions. Speckle-tracking echocardiography can detect early subclinical left ventricular systolic dysfunction via the left ventricular global longitudinal strain compared with conventional echocardiographic parameters in patients with septic shock. |
| format | Article |
| id | doaj-art-3fde8a7da4674bcdac55fff3abe42389 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-3fde8a7da4674bcdac55fff3abe423892025-02-03T06:43:32ZengWileyCritical Care Research and Practice2090-13052090-13132020-01-01202010.1155/2020/60986546098654Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography StudyPham Dang Hai0Le Lan Phuong1Nguyen Manh Dung2Le Thi Viet Hoa3Do Van Quyen4Nguyen Xuan Chinh5Vu Duy Minh6Pham Nguyen Son7Intensive Care Unit, 108 Military Central Hospital, Ha Noi, VietnamIntensive Care Unit, 108 Military Central Hospital, Ha Noi, VietnamIntensive Care Unit, 108 Military Central Hospital, Ha Noi, VietnamIntensive Care Unit, Tam Anh General Hospital, Ha Noi, VietnamUltrasound Department, 108 Military Central Hospital, Ha Noi, VietnamIntensive Care Unit, 108 Military Central Hospital, Ha Noi, VietnamDepartment of Emergency, 108 Military Central Hospital, Ha Noi, VietnamDepartment of Cardiology, 108 Military Central Hospital, Ha Noi, VietnamIntroduction. Left ventricular dysfunction is quite common in septic shock. Speckle-tracking echocardiography (STE) is a novel, highly sensitive method for assessing left ventricular function, capable of detecting subclinical myocardial dysfunction, which is not identified with conventional echocardiography. We sought to evaluate subclinical left ventricular systolic function in patients with septic shock using speckle-tracking echocardiography. Methods. From May 2017 to December 2018, patients aged ≥18 years admitted to the intensive care unit with the diagnosis of sepsis and septic shock based on the sepsis-3 definition were included. Patients with other causes of cardiac dysfunction were excluded. Transthoracic echocardiography was performed for all the patients within 24 hours of diagnosis. Left ventricular systolic function was assessed using conventional echocardiography and speckle-tracking echocardiography. Results. Patients with septic shock (n = 90) (study group) and 37 matched patients with sepsis but no septic shock (control group) were included. Left ventricular ejection fraction (LVEF) by conventional echocardiography showed no significant difference between two groups (58.2 ± 9.9 vs. 58.6 ± 8.3, p=0.804). The global longitudinal strain (GLS) by STE was significantly reduced in patients with septic shock compared with that in the control (−14.6 ± 3.3 vs. −17.1 ± 3.3, p<0.001). Based on the cutoff value of GLS ≥ −15% for the definition of subclinical left ventricular systolic dysfunction, this dysfunction was detected in 50 patients with septic shock (55.6%) and in 6 patients in the control group (16.2%) (p<0.05). Conclusions. Speckle-tracking echocardiography can detect early subclinical left ventricular systolic dysfunction via the left ventricular global longitudinal strain compared with conventional echocardiographic parameters in patients with septic shock.http://dx.doi.org/10.1155/2020/6098654 |
| spellingShingle | Pham Dang Hai Le Lan Phuong Nguyen Manh Dung Le Thi Viet Hoa Do Van Quyen Nguyen Xuan Chinh Vu Duy Minh Pham Nguyen Son Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study Critical Care Research and Practice |
| title | Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study |
| title_full | Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study |
| title_fullStr | Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study |
| title_full_unstemmed | Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study |
| title_short | Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study |
| title_sort | subclinical left ventricular systolic dysfunction in patients with septic shock based on sepsis 3 definition a speckle tracking echocardiography study |
| url | http://dx.doi.org/10.1155/2020/6098654 |
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