The skin allergy risk assessment-integrated chemical environment (SARA-ICE) defined approach to derive points of departure for skin sensitization

The skin allergy risk assessment-integrated chemical environment (SARA-ICE) defined approach to derive points of departure for skin sensitization

Mechanistically based non-animal methods for assessing skin sensitization hazard have been developed, but are not considered sufficient, individually, to conclusively define the skin sensitization potential or potency of a chemical. This resulted in the development of defined approaches (DAs), as do...

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Bibliographic Details
Main Authors: Emily N. Reinke, Joe Reynolds, Nicola Gilmour, Georgia Reynolds, Judy Strickland, Dori Germolec, David G. Allen, Gavin Maxwell, Nicole C. Kleinstreuer
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Toxicology
Subjects:
Skin sensitization
Non-animal methodology
Risk assessment
LLNA
Point of departure
Bayesian
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X24000586
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