Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation
ABSTRACT Introduction The provision of treatment for epidermal growth factor receptor (EGFR)‐mutated nonsmall cell lung cancer (NSCLC) patients has increased in Korea. However, multicenter studies on the clinicopathologic dataset and treatment outcomes, using a large‐scale dataset, have not been con...
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Wiley
2025-01-01
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| Series: | The Clinical Respiratory Journal |
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| Online Access: | https://doi.org/10.1111/crj.70043 |
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| author | Chang Dong Yeo Dong Won Park Seong Hoon Yoon Eun Young Kim Jeong Eun Lee Shin Yup Lee Chang‐Min Choi In‐Jae Oh Do Jin Kim Jeong Seon Ryu Jae Cheol Lee Young‐Chul Kim Tae Won Jang Kye Young Lee Seung Hun Jang Seung Joon Kim for the Korean EGFR Registry Investigators |
| author_facet | Chang Dong Yeo Dong Won Park Seong Hoon Yoon Eun Young Kim Jeong Eun Lee Shin Yup Lee Chang‐Min Choi In‐Jae Oh Do Jin Kim Jeong Seon Ryu Jae Cheol Lee Young‐Chul Kim Tae Won Jang Kye Young Lee Seung Hun Jang Seung Joon Kim for the Korean EGFR Registry Investigators |
| author_sort | Chang Dong Yeo |
| collection | DOAJ |
| description | ABSTRACT Introduction The provision of treatment for epidermal growth factor receptor (EGFR)‐mutated nonsmall cell lung cancer (NSCLC) patients has increased in Korea. However, multicenter studies on the clinicopathologic dataset and treatment outcomes, using a large‐scale dataset, have not been conducted. The current study is a prospective and retrospective multicenter observational cohort study that registers all stages of EGFR‐mutated NSCLC patients. Methods The Korean EGFR Registry was designed to enroll 2000 patients with all stages of EGFR‐mutated NSCLC from 40 university hospitals across Korea. This study, encompassing both retrospective and prospective cohorts, aims to analyze clinical characteristics, treatment modalities, and outcomes in these patients. Data collection will include patient demographics, smoking history, quality of life assessments, pathological data, and treatment outcomes, with follow‐up until December 2026. The primary endpoint is disease‐free survival in patients who have undergone radical therapy (surgery and radiotherapy) or progression‐free survival in those receiving targeted therapy (first, second, and subsequent lines), chemotherapy (first and subsequent lines), combination therapy, and palliative/maintenance therapy according to stages of EGFR‐mutated NSCLC. The study will explore the diagnostic methods for EGFR mutations, clinical outcomes based on treatment modalities, and metastatic patterns in EGFR‐mutated NSCLC patients. Moreover, it will investigate various aspects, including the safety and efficacy of a new third‐generation EGFR tyrosine kinase inhibitor (TKI), lazertinib, approved for both first‐ and second‐line treatments. Discussion This study is expected to provide valuable insights into the epidemiology, risk factors, progression, and treatment outcomes of EGFR‐mutated NSCLC in Korea. The Korean EGFR Registry will contribute significantly to the understanding of the complex dynamics of EGFR‐mutated NSCLC, aiding in the development of more effective and personalized treatment strategies. |
| format | Article |
| id | doaj-art-3fb605ae76744a449c66ce483f93673b |
| institution | Kabale University |
| issn | 1752-6981 1752-699X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj-art-3fb605ae76744a449c66ce483f93673b2025-01-27T08:28:30ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2025-01-01191n/an/a10.1111/crj.70043Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR MutationChang Dong Yeo0Dong Won Park1Seong Hoon Yoon2Eun Young Kim3Jeong Eun Lee4Shin Yup Lee5Chang‐Min Choi6In‐Jae Oh7Do Jin Kim8Jeong Seon Ryu9Jae Cheol Lee10Young‐Chul Kim11Tae Won Jang12Kye Young Lee13Seung Hun Jang14Seung Joon Kim15for the Korean EGFR Registry InvestigatorsDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine Catholic University of Korea Seoul Republic of KoreaDivision of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang Medical Center Hanyang University College of Medicine Seoul Republic of KoreaDepartment of Internal Medicine Pusan National University Yangsan Hospital Yangsan Republic of KoreaDivision of Pulmonology, Department of Internal Medicine, Severance Hospital Yonsei University College of Medicine Seoul Republic of KoreaDivision of Pulmonology, Department of Internal Medicine, College of Medicine Chungnam National University Daejeon Republic of KoreaDepartment of Internal Medicine Kyungpook National University School of Medicine Daegu Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of KoreaDepartment of Internal Medicine Chonnam National University Medical School and Hwasun Hospital Hwasun Republic of KoreaDivision of Respiratory‐Allergy, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital Soonchunhyang University College of Medicine Bucheon Republic of KoreaDepartment of Internal Medicine Inha University Hospital Incheon Republic of KoreaDepartment of Oncology, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of KoreaDepartment of Internal Medicine Chonnam National University Medical School and Hwasun Hospital Hwasun Republic of KoreaDepartment of Internal Medicine Kosin University Medical College Pusan Republic of KoreaDepartment of Pulmonary Medicine Konkuk University School of Medicine Seoul Republic of KoreaDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang Republic of KoreaDivision of Pulmonology, Department of Internal Medicine, Seoul St. Mary's Hospital Catholic University of Korea Seoul Republic of KoreaABSTRACT Introduction The provision of treatment for epidermal growth factor receptor (EGFR)‐mutated nonsmall cell lung cancer (NSCLC) patients has increased in Korea. However, multicenter studies on the clinicopathologic dataset and treatment outcomes, using a large‐scale dataset, have not been conducted. The current study is a prospective and retrospective multicenter observational cohort study that registers all stages of EGFR‐mutated NSCLC patients. Methods The Korean EGFR Registry was designed to enroll 2000 patients with all stages of EGFR‐mutated NSCLC from 40 university hospitals across Korea. This study, encompassing both retrospective and prospective cohorts, aims to analyze clinical characteristics, treatment modalities, and outcomes in these patients. Data collection will include patient demographics, smoking history, quality of life assessments, pathological data, and treatment outcomes, with follow‐up until December 2026. The primary endpoint is disease‐free survival in patients who have undergone radical therapy (surgery and radiotherapy) or progression‐free survival in those receiving targeted therapy (first, second, and subsequent lines), chemotherapy (first and subsequent lines), combination therapy, and palliative/maintenance therapy according to stages of EGFR‐mutated NSCLC. The study will explore the diagnostic methods for EGFR mutations, clinical outcomes based on treatment modalities, and metastatic patterns in EGFR‐mutated NSCLC patients. Moreover, it will investigate various aspects, including the safety and efficacy of a new third‐generation EGFR tyrosine kinase inhibitor (TKI), lazertinib, approved for both first‐ and second‐line treatments. Discussion This study is expected to provide valuable insights into the epidemiology, risk factors, progression, and treatment outcomes of EGFR‐mutated NSCLC in Korea. The Korean EGFR Registry will contribute significantly to the understanding of the complex dynamics of EGFR‐mutated NSCLC, aiding in the development of more effective and personalized treatment strategies.https://doi.org/10.1111/crj.70043EGFRKoreanlung cancerregistry study |
| spellingShingle | Chang Dong Yeo Dong Won Park Seong Hoon Yoon Eun Young Kim Jeong Eun Lee Shin Yup Lee Chang‐Min Choi In‐Jae Oh Do Jin Kim Jeong Seon Ryu Jae Cheol Lee Young‐Chul Kim Tae Won Jang Kye Young Lee Seung Hun Jang Seung Joon Kim for the Korean EGFR Registry Investigators Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation The Clinical Respiratory Journal EGFR Korean lung cancer registry study |
| title | Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation |
| title_full | Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation |
| title_fullStr | Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation |
| title_full_unstemmed | Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation |
| title_short | Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation |
| title_sort | study protocol of the korean egfr registry a multicenter prospective and retrospective cohort study in nonsmall cell lung cancer patients with egfr mutation |
| topic | EGFR Korean lung cancer registry study |
| url | https://doi.org/10.1111/crj.70043 |
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