Utility of D-dimer and other biomarkers in COVID-19 patients - A prospective study in a tertiary care center
Background: Clinical status and concurrent comorbidities of COVID-19 patients largely determine the need for their admittance to ICUs, similarly, several laboratory parameters like D-dimer, LDH, serum ferritin, CRP, and IL-6 may facilitate the assessment of disease severity and rational triaging. Th...
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Association of Clinical Pathologists of Nepal
2022-09-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/37752 |
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| author | Indira Priyadarshini A Jayalaxmi Yadav K Shridevi SH Bharat C |
| author_facet | Indira Priyadarshini A Jayalaxmi Yadav K Shridevi SH Bharat C |
| author_sort | Indira Priyadarshini A |
| collection | DOAJ |
| description | Background: Clinical status and concurrent comorbidities of COVID-19 patients largely determine the need for their admittance to ICUs, similarly, several laboratory parameters like D-dimer, LDH, serum ferritin, CRP, and IL-6 may facilitate the assessment of disease severity and rational triaging. Therefore, their role in the management of COVID-19 patients has to be assessed.
Materials and methods: Prospective study was done on patients who were tested positive for COVID-19 infection and admitted to various centers under the Vijayanagara Institute of Medical Sciences, India. Patients were divided into mild, moderate, and severe cases. Demographic data and serum levels of biomarkers like D-dimer, LDH, ferritin, CRP, and IL-6 were collected in these patients, and data were statistically analyzed.
Results: A total of 164 cases were included in this study, of which, 62 were mild, 47 moderate, and 55 were severely infected COVID-19 patients. There was male predominance in patients infected with COVID-19. The median age of presentation was 53, 60, and 57 years in mild, moderate, and severe cases respectively. Median was also derived for D-dimer, LDH, serum ferritin, CRP, and IL-6 in mild, moderate, and severe cases. Changes in D-dimer, LDH, and serum ferritin levels in mild, moderate, and severe cases showed statistical significance(p<0.05).
Conclusions: D-dimer helps in the early identification of mild, moderate, and severe cases and can be used for the vigilant monitoring of patients. LDH and serum ferritin helps in the identification of oxygen-dependent and oxygen-independent patients. The role of CRP and IL-6 in the management of COVID-19 patients has to be further investigated. |
| format | Article |
| id | doaj-art-3faefb0dca004c8daace7db9a11a64ff |
| institution | Kabale University |
| issn | 2091-0797 2091-0908 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj-art-3faefb0dca004c8daace7db9a11a64ff2025-08-21T07:03:01ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082022-09-011221950195510.3126/jpn.v12i2.3775234539Utility of D-dimer and other biomarkers in COVID-19 patients - A prospective study in a tertiary care centerIndira Priyadarshini A0https://orcid.org/0000-0002-2528-1713Jayalaxmi Yadav K1https://orcid.org/0000-0001-8686-5336Shridevi SH2https://orcid.org/0000-0002-2528-1713Bharat C3https://orcid.org/0000-0002-2528-1713Vijayanagara Institute of Medical Sciences, Karnataka, IndiaVijayanagara Institute of Medical Sciences, Karnataka, IndiaVijayanagara Institute of Medical Sciences, Karnataka, IndiaVijayanagara Institute of Medical Sciences, Karnataka, IndiaBackground: Clinical status and concurrent comorbidities of COVID-19 patients largely determine the need for their admittance to ICUs, similarly, several laboratory parameters like D-dimer, LDH, serum ferritin, CRP, and IL-6 may facilitate the assessment of disease severity and rational triaging. Therefore, their role in the management of COVID-19 patients has to be assessed. Materials and methods: Prospective study was done on patients who were tested positive for COVID-19 infection and admitted to various centers under the Vijayanagara Institute of Medical Sciences, India. Patients were divided into mild, moderate, and severe cases. Demographic data and serum levels of biomarkers like D-dimer, LDH, ferritin, CRP, and IL-6 were collected in these patients, and data were statistically analyzed. Results: A total of 164 cases were included in this study, of which, 62 were mild, 47 moderate, and 55 were severely infected COVID-19 patients. There was male predominance in patients infected with COVID-19. The median age of presentation was 53, 60, and 57 years in mild, moderate, and severe cases respectively. Median was also derived for D-dimer, LDH, serum ferritin, CRP, and IL-6 in mild, moderate, and severe cases. Changes in D-dimer, LDH, and serum ferritin levels in mild, moderate, and severe cases showed statistical significance(p<0.05). Conclusions: D-dimer helps in the early identification of mild, moderate, and severe cases and can be used for the vigilant monitoring of patients. LDH and serum ferritin helps in the identification of oxygen-dependent and oxygen-independent patients. The role of CRP and IL-6 in the management of COVID-19 patients has to be further investigated.https://www.nepjol.info/index.php/JPN/article/view/37752c-reactive protein; d-dimer; ferritin; interleukin-6; lactate dehydrogenase; |
| spellingShingle | Indira Priyadarshini A Jayalaxmi Yadav K Shridevi SH Bharat C Utility of D-dimer and other biomarkers in COVID-19 patients - A prospective study in a tertiary care center Journal of Pathology of Nepal c-reactive protein; d-dimer; ferritin; interleukin-6; lactate dehydrogenase; |
| title | Utility of D-dimer and other biomarkers in COVID-19 patients - A prospective study in a tertiary care center |
| title_full | Utility of D-dimer and other biomarkers in COVID-19 patients - A prospective study in a tertiary care center |
| title_fullStr | Utility of D-dimer and other biomarkers in COVID-19 patients - A prospective study in a tertiary care center |
| title_full_unstemmed | Utility of D-dimer and other biomarkers in COVID-19 patients - A prospective study in a tertiary care center |
| title_short | Utility of D-dimer and other biomarkers in COVID-19 patients - A prospective study in a tertiary care center |
| title_sort | utility of d dimer and other biomarkers in covid 19 patients a prospective study in a tertiary care center |
| topic | c-reactive protein; d-dimer; ferritin; interleukin-6; lactate dehydrogenase; |
| url | https://www.nepjol.info/index.php/JPN/article/view/37752 |
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