Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk

Polyp and tumor microenvironment reprogramming in colorectal cancer: insights from mucosal bacteriome and metabolite crosstalk

Abstract Background Highly frequent colorectal cancer (CRC) is predicted to have 3.2 million novel cases by 2040. Tumor microenvironment (TME) bacteriome and metabolites are proposed to be involved in CRC development. In this regard, we aimed to investigate the bacteriome and metabolites of healthy,...

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Main Authors: Hadi Feizi, Hossein Samadi Kafil, Andrey Plotnikov, Vladimir Kataev, Alexander Balkin, Ekaterina Filonchikova, Mohammad Ahangarzadeh Rezaee, Reza Ghotaslou, Mohammad Sadrkabir, Hiva Kadkhoda, Fadhil S. Kamounah, Sergei Nikitin
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Annals of Clinical Microbiology and Antimicrobials
Subjects:
Colorectal cancer
Gut microbiome
Gut metabolome
Tumor microenvironment
Fusobacterium nucleatum
Online Access:https://doi.org/10.1186/s12941-025-00777-9
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