SEGREGATION MODELS OF COMPLEX QUANTITATIVE TRAITS AND LINKAGE ANALYSIS IN EXTENDED RECOMBINANT INBRED CROSSES
This paper introduces classes of segregation models, which describe the inheritance of a quantitative trait, in extended diallelic recombinant inbred crosses. The distinctive feature of the method is usage of the multiple-QTL approach and incorporation of epistatic interactions of loci groups. Solut...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-01-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/194 |
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| author | M. S. Diakov A. V. Osadchuk |
| author_facet | M. S. Diakov A. V. Osadchuk |
| author_sort | M. S. Diakov |
| collection | DOAJ |
| description | This paper introduces classes of segregation models, which describe the inheritance of a quantitative trait, in extended diallelic recombinant inbred crosses. The distinctive feature of the method is usage of the multiple-QTL approach and incorporation of epistatic interactions of loci groups. Solutions that would describe experimental data set to an accuracy of environmental variance are sought in the constructed classes of models. Then linkage analysis is performed: model loci positions of the found solutions are mapped on chromosomes. The search procedure and linkage analysis have been tested with real data on cerebellum weight in laboratory mice as a quantitative trait. The developed software is briefly described. |
| format | Article |
| id | doaj-art-3fa493cd595e4f768730eb549f34ce24 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-3fa493cd595e4f768730eb549f34ce242025-02-01T09:58:00ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592015-01-01174/1705713178SEGREGATION MODELS OF COMPLEX QUANTITATIVE TRAITS AND LINKAGE ANALYSIS IN EXTENDED RECOMBINANT INBRED CROSSESM. S. Diakov0A. V. Osadchuk1Institute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaThis paper introduces classes of segregation models, which describe the inheritance of a quantitative trait, in extended diallelic recombinant inbred crosses. The distinctive feature of the method is usage of the multiple-QTL approach and incorporation of epistatic interactions of loci groups. Solutions that would describe experimental data set to an accuracy of environmental variance are sought in the constructed classes of models. Then linkage analysis is performed: model loci positions of the found solutions are mapped on chromosomes. The search procedure and linkage analysis have been tested with real data on cerebellum weight in laboratory mice as a quantitative trait. The developed software is briefly described.https://vavilov.elpub.ru/jour/article/view/194segregation analysiscomplex quantitative traitsmultiple-qtl approachlinkage analysisregression analysisepistatic interactionsrecombinant inbred strainsextended diallelic crossesinformation technologies of data analysis |
| spellingShingle | M. S. Diakov A. V. Osadchuk SEGREGATION MODELS OF COMPLEX QUANTITATIVE TRAITS AND LINKAGE ANALYSIS IN EXTENDED RECOMBINANT INBRED CROSSES Вавиловский журнал генетики и селекции segregation analysis complex quantitative traits multiple-qtl approach linkage analysis regression analysis epistatic interactions recombinant inbred strains extended diallelic crosses information technologies of data analysis |
| title | SEGREGATION MODELS OF COMPLEX QUANTITATIVE TRAITS AND LINKAGE ANALYSIS IN EXTENDED RECOMBINANT INBRED CROSSES |
| title_full | SEGREGATION MODELS OF COMPLEX QUANTITATIVE TRAITS AND LINKAGE ANALYSIS IN EXTENDED RECOMBINANT INBRED CROSSES |
| title_fullStr | SEGREGATION MODELS OF COMPLEX QUANTITATIVE TRAITS AND LINKAGE ANALYSIS IN EXTENDED RECOMBINANT INBRED CROSSES |
| title_full_unstemmed | SEGREGATION MODELS OF COMPLEX QUANTITATIVE TRAITS AND LINKAGE ANALYSIS IN EXTENDED RECOMBINANT INBRED CROSSES |
| title_short | SEGREGATION MODELS OF COMPLEX QUANTITATIVE TRAITS AND LINKAGE ANALYSIS IN EXTENDED RECOMBINANT INBRED CROSSES |
| title_sort | segregation models of complex quantitative traits and linkage analysis in extended recombinant inbred crosses |
| topic | segregation analysis complex quantitative traits multiple-qtl approach linkage analysis regression analysis epistatic interactions recombinant inbred strains extended diallelic crosses information technologies of data analysis |
| url | https://vavilov.elpub.ru/jour/article/view/194 |
| work_keys_str_mv | AT msdiakov segregationmodelsofcomplexquantitativetraitsandlinkageanalysisinextendedrecombinantinbredcrosses AT avosadchuk segregationmodelsofcomplexquantitativetraitsandlinkageanalysisinextendedrecombinantinbredcrosses |