Computational modeling approaches to studying the dynamics of oncolytic viruses
Oncolytic viruses specifically infect cancer cells, replicate in them, killthem, and spread to further tumor cells. They represent a targeted treatmentapproach that is promising in principle, but consistent success has yet tobe observed. Mathematical models can play an important role in analyzing th...
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| Format: | Article |
| Language: | English |
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AIMS Press
2013-03-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.939 |
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| Summary: | Oncolytic viruses specifically infect cancer cells, replicate in them, killthem, and spread to further tumor cells. They represent a targeted treatmentapproach that is promising in principle, but consistent success has yet tobe observed. Mathematical models can play an important role in analyzing thedynamics between oncolytic viruses and a growing tumor cell population,providing insights that can be useful for the further development of thistherapy approach. This article reviews different mathematical modelingapproaches ranging from ordinary differential equations to spatiallyexplicit agent-based models. Problems of model robustness are discussed andso are some clinically important insight derived from the models. |
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| ISSN: | 1551-0018 |