Killing hepatocellular carcinoma in the NAFLD/NASH stage: a comprehensive perspective on targeting regulated cell death
Abstract Nonalcoholic steatohepatitis (NASH) has been identified as a significant risk factor contributing to the rising incidence of hepatocellular carcinoma (HCC). With the evolving epidemiological characteristics of NASH, the incidence of NASH-related HCC has increased substantially. Recent advan...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-06-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02558-x |
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| _version_ | 1849329020963913728 |
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| author | Jianxin Xi Shuangyin Lei Jie Chen Jiahui Liu Chenhao Shan Xun Sun Qianqian Zheng Xiaoju Shi |
| author_facet | Jianxin Xi Shuangyin Lei Jie Chen Jiahui Liu Chenhao Shan Xun Sun Qianqian Zheng Xiaoju Shi |
| author_sort | Jianxin Xi |
| collection | DOAJ |
| description | Abstract Nonalcoholic steatohepatitis (NASH) has been identified as a significant risk factor contributing to the rising incidence of hepatocellular carcinoma (HCC). With the evolving epidemiological characteristics of NASH, the incidence of NASH-related HCC has increased substantially. Recent advances in the study of regulated cell death (RCD) mechanisms have uncovered their roles in the pathogenesis of NAFLD/NASH and associated HCC, offering novel insights and directions for targeted therapeutic strategies. Although numerous studies have highlighted the critical role of RCD mechanisms in NAFLD/NASH and related HCC, significant challenges remain in developing effective targeted therapies and translating them into clinical applications. This review aims to summarize the current progress in understanding the role of RCD in NAFLD/NASH and associated HCC, explore potential therapeutic strategies and clinical applications, and provide new perspectives and therapeutic targets for treating NAFLD/NASH. Ultimately, the goal is to control disease progression at the NAFLD/NASH stage and prevent its progression to HCC. |
| format | Article |
| id | doaj-art-3f9e11780ddb4e359d18656d717e2f43 |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-3f9e11780ddb4e359d18656d717e2f432025-08-20T03:47:24ZengNature Publishing GroupCell Death Discovery2058-77162025-06-0111113010.1038/s41420-025-02558-xKilling hepatocellular carcinoma in the NAFLD/NASH stage: a comprehensive perspective on targeting regulated cell deathJianxin Xi0Shuangyin Lei1Jie Chen2Jiahui Liu3Chenhao Shan4Xun Sun5Qianqian Zheng6Xiaoju Shi7Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin UniversityDepartment of Neurology, The First Hospital of Jilin UniversityDepartment of Radiology, The First Hospital of Jilin UniversityBasic Medicine College, China Medical UniversityBasic Medicine College, China Medical UniversityDepartment of Immunology, Basic Medicine College, China Medical UniversityDepartment of Pathophysiology, Basic Medicine College, China Medical UniversityDepartment of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin UniversityAbstract Nonalcoholic steatohepatitis (NASH) has been identified as a significant risk factor contributing to the rising incidence of hepatocellular carcinoma (HCC). With the evolving epidemiological characteristics of NASH, the incidence of NASH-related HCC has increased substantially. Recent advances in the study of regulated cell death (RCD) mechanisms have uncovered their roles in the pathogenesis of NAFLD/NASH and associated HCC, offering novel insights and directions for targeted therapeutic strategies. Although numerous studies have highlighted the critical role of RCD mechanisms in NAFLD/NASH and related HCC, significant challenges remain in developing effective targeted therapies and translating them into clinical applications. This review aims to summarize the current progress in understanding the role of RCD in NAFLD/NASH and associated HCC, explore potential therapeutic strategies and clinical applications, and provide new perspectives and therapeutic targets for treating NAFLD/NASH. Ultimately, the goal is to control disease progression at the NAFLD/NASH stage and prevent its progression to HCC.https://doi.org/10.1038/s41420-025-02558-x |
| spellingShingle | Jianxin Xi Shuangyin Lei Jie Chen Jiahui Liu Chenhao Shan Xun Sun Qianqian Zheng Xiaoju Shi Killing hepatocellular carcinoma in the NAFLD/NASH stage: a comprehensive perspective on targeting regulated cell death Cell Death Discovery |
| title | Killing hepatocellular carcinoma in the NAFLD/NASH stage: a comprehensive perspective on targeting regulated cell death |
| title_full | Killing hepatocellular carcinoma in the NAFLD/NASH stage: a comprehensive perspective on targeting regulated cell death |
| title_fullStr | Killing hepatocellular carcinoma in the NAFLD/NASH stage: a comprehensive perspective on targeting regulated cell death |
| title_full_unstemmed | Killing hepatocellular carcinoma in the NAFLD/NASH stage: a comprehensive perspective on targeting regulated cell death |
| title_short | Killing hepatocellular carcinoma in the NAFLD/NASH stage: a comprehensive perspective on targeting regulated cell death |
| title_sort | killing hepatocellular carcinoma in the nafld nash stage a comprehensive perspective on targeting regulated cell death |
| url | https://doi.org/10.1038/s41420-025-02558-x |
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