Advances in nanoparticle-based radiotherapy for cancer treatment
Summary: Radiotherapy has long been recognized as an effective conventional approach in both clinical and scientific research, primarily through mechanisms involving DNA destruction or the generation of reactive oxygen species to target tumors. However, significant challenges persist, including the...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224028293 |
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| author | Meijuan He Shixiong Chen Hongwei Yu Xuhui Fan Hong Wu Yihui Wang Han Wang Xiaorui Yin |
| author_facet | Meijuan He Shixiong Chen Hongwei Yu Xuhui Fan Hong Wu Yihui Wang Han Wang Xiaorui Yin |
| author_sort | Meijuan He |
| collection | DOAJ |
| description | Summary: Radiotherapy has long been recognized as an effective conventional approach in both clinical and scientific research, primarily through mechanisms involving DNA destruction or the generation of reactive oxygen species to target tumors. However, significant challenges persist, including the unavoidable damage to normal tissues and the development of radiation resistance. As a result, nanotechnology-based radiotherapy has garnered considerable attention for its potential to enhance precision in irradiation, improve radiosensitization, and achieve therapeutic advancements. Importantly, radiotherapy alone frequently falls short of fully eradicating tumors. Consequently, to augment the efficacy of radiotherapy, it is often integrated with other therapeutic strategies. This review elucidates the mechanisms of radiotherapy sensitization based on diverse nanoparticles. Typically, radiotherapy is sensitized through augmenting reactive oxygen species production, targeted radiotherapy, hypoxia relief, enhancement of antitumor immune microenvironment, and G2/M cell cycle arrest. Moreover, the incorporation of nanoparticle-based anti-tumor strategies with radiotherapy markedly enhances the current state of radiotherapy. Additionally, a compilation of clinical trials utilizing nano-radioenhancers is presented. Finally, future prospects for clinical translation in this field are thoroughly examined. |
| format | Article |
| id | doaj-art-3f8d64c68bc843418ff2bc61d76f67b1 |
| institution | DOAJ |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-3f8d64c68bc843418ff2bc61d76f67b12025-08-20T02:39:59ZengElsevieriScience2589-00422025-01-0128111160210.1016/j.isci.2024.111602Advances in nanoparticle-based radiotherapy for cancer treatmentMeijuan He0Shixiong Chen1Hongwei Yu2Xuhui Fan3Hong Wu4Yihui Wang5Han Wang6Xiaorui Yin7Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; Shanghai General Hospital Branch of National Center for Translational Medicine (Shanghai), Shanghai 201620, ChinaDepartment of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; Shanghai General Hospital Branch of National Center for Translational Medicine (Shanghai), Shanghai 201620, ChinaDepartment of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; Shanghai General Hospital Branch of National Center for Translational Medicine (Shanghai), Shanghai 201620, China; Jiading Branch of Shanghai General Hospital, Shanghai 201803, China; Corresponding authorDepartment of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; Corresponding authorSummary: Radiotherapy has long been recognized as an effective conventional approach in both clinical and scientific research, primarily through mechanisms involving DNA destruction or the generation of reactive oxygen species to target tumors. However, significant challenges persist, including the unavoidable damage to normal tissues and the development of radiation resistance. As a result, nanotechnology-based radiotherapy has garnered considerable attention for its potential to enhance precision in irradiation, improve radiosensitization, and achieve therapeutic advancements. Importantly, radiotherapy alone frequently falls short of fully eradicating tumors. Consequently, to augment the efficacy of radiotherapy, it is often integrated with other therapeutic strategies. This review elucidates the mechanisms of radiotherapy sensitization based on diverse nanoparticles. Typically, radiotherapy is sensitized through augmenting reactive oxygen species production, targeted radiotherapy, hypoxia relief, enhancement of antitumor immune microenvironment, and G2/M cell cycle arrest. Moreover, the incorporation of nanoparticle-based anti-tumor strategies with radiotherapy markedly enhances the current state of radiotherapy. Additionally, a compilation of clinical trials utilizing nano-radioenhancers is presented. Finally, future prospects for clinical translation in this field are thoroughly examined.http://www.sciencedirect.com/science/article/pii/S2589004224028293Health sciencesNatural sciencesApplied sciences |
| spellingShingle | Meijuan He Shixiong Chen Hongwei Yu Xuhui Fan Hong Wu Yihui Wang Han Wang Xiaorui Yin Advances in nanoparticle-based radiotherapy for cancer treatment iScience Health sciences Natural sciences Applied sciences |
| title | Advances in nanoparticle-based radiotherapy for cancer treatment |
| title_full | Advances in nanoparticle-based radiotherapy for cancer treatment |
| title_fullStr | Advances in nanoparticle-based radiotherapy for cancer treatment |
| title_full_unstemmed | Advances in nanoparticle-based radiotherapy for cancer treatment |
| title_short | Advances in nanoparticle-based radiotherapy for cancer treatment |
| title_sort | advances in nanoparticle based radiotherapy for cancer treatment |
| topic | Health sciences Natural sciences Applied sciences |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224028293 |
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