AAV capsids target muscle-resident cells with different efficiencies—A comparative study between AAV8, AAVMYO, and AAVMYO2

AAV capsids target muscle-resident cells with different efficiencies—A comparative study between AAV8, AAVMYO, and AAVMYO2

Adeno-associated viruses (AAVs) of different serotypes are commonly used in gene therapies and gene interrogation studies to deliver transgenes to skeletal muscle in humans and mice. While efficient muscle fiber transduction is possible, little is known of their capacity to transduce muscle-residing...

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Bibliographic Details
Main Authors: Timothy J. McGowan, Nicolas Lewerenz, Eleonora Maino, Marco Thürkauf, Lena Jörin, Markus A. Rüegg
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
skeletal muscle
gene therapy
muscle stem cells
immune cells
endothelial cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125000464
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