Synthesis and Biological Evaluation of New CRH Analogues

Synthesis and Biological Evaluation of New CRH Analogues

A series of 7 new human/rat Corticotropin Releasing Hormone (h/r-CRH) analogues were synthesized. The induced alterations include substitution of Phe at position 12 with D-Phe, Leu at positions 14 and 15 with Aib and Met at positions 21 and 38 with Cys(Et) and Cys(Pr). The analogues were tested rega...

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Bibliographic Details
Main Authors: Spyridon Papazacharias, Vassiliki Magafa, Nicole Bernad, George Pairas, Georgios A. Spyroulias, Jean Martinez, Paul Cordopatis
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/2010/252348
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