Parenteral Antibiotics Reduce Bifidobacteria Colonization and Diversity in Neonates
We investigated the impact of parenteral antibiotic treatment in the early neonatal period on the evolution of bifidobacteria in the newborn. Nine babies treated with intravenous ampicillin/gentamicin in the first week of life and nine controls (no antibiotic treatment) were studied. Denaturing grad...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2011/130574 |
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| author | Séamus Hussey Rebecca Wall Emma Gruffman Lisa O'Sullivan C. Anthony Ryan Brendan Murphy Gerald Fitzgerald Catherine Stanton R. Paul Ross |
| author_facet | Séamus Hussey Rebecca Wall Emma Gruffman Lisa O'Sullivan C. Anthony Ryan Brendan Murphy Gerald Fitzgerald Catherine Stanton R. Paul Ross |
| author_sort | Séamus Hussey |
| collection | DOAJ |
| description | We investigated the impact of parenteral antibiotic treatment in the early neonatal period on the evolution of bifidobacteria in the newborn. Nine babies treated with intravenous ampicillin/gentamicin in the first week of life and nine controls (no antibiotic treatment) were studied. Denaturing gradient gel electrophoresis was used to investigate the composition of Bifidobacterium in stool samples taken at four and eight weeks. Bifidobacteria were detected in all control infants at both four and eight weeks, while only six of nine antibiotic-treated infants had detectable bifidobacteria at four weeks and eight of nine at eight weeks. Moreover, stool samples of controls showed greater diversity of Bifidobacterium spp. compared with antibiotic-treated infants. In conclusion, short-term parenteral antibiotic treatment of neonates causes a disturbance in the expected colonization pattern of bifidobacteria in the first months of life. Further studies are required to probiotic determine if supplementation is necessary in this patient group. |
| format | Article |
| id | doaj-art-3f80f439ea8e41faae522f72b624b19a |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-3f80f439ea8e41faae522f72b624b19a2025-02-03T06:00:12ZengWileyInternational Journal of Microbiology1687-918X1687-91982011-01-01201110.1155/2011/130574130574Parenteral Antibiotics Reduce Bifidobacteria Colonization and Diversity in NeonatesSéamus Hussey0Rebecca Wall1Emma Gruffman2Lisa O'Sullivan3C. Anthony Ryan4Brendan Murphy5Gerald Fitzgerald6Catherine Stanton7R. Paul Ross8Department of Paediatrics and Child Health, University College Cork, Cork, IrelandAlimentary Pharmabiotic Centre, Cork, IrelandDepartment of Biotechnology, Teagasc Moorepark Food Research Centre, Fermoy, Cork, IrelandDepartment of Biotechnology, Teagasc Moorepark Food Research Centre, Fermoy, Cork, IrelandDepartment of Paediatrics and Child Health, University College Cork, Cork, IrelandDepartment of Paediatrics and Child Health, University College Cork, Cork, IrelandAlimentary Pharmabiotic Centre, Cork, IrelandAlimentary Pharmabiotic Centre, Cork, IrelandAlimentary Pharmabiotic Centre, Cork, IrelandWe investigated the impact of parenteral antibiotic treatment in the early neonatal period on the evolution of bifidobacteria in the newborn. Nine babies treated with intravenous ampicillin/gentamicin in the first week of life and nine controls (no antibiotic treatment) were studied. Denaturing gradient gel electrophoresis was used to investigate the composition of Bifidobacterium in stool samples taken at four and eight weeks. Bifidobacteria were detected in all control infants at both four and eight weeks, while only six of nine antibiotic-treated infants had detectable bifidobacteria at four weeks and eight of nine at eight weeks. Moreover, stool samples of controls showed greater diversity of Bifidobacterium spp. compared with antibiotic-treated infants. In conclusion, short-term parenteral antibiotic treatment of neonates causes a disturbance in the expected colonization pattern of bifidobacteria in the first months of life. Further studies are required to probiotic determine if supplementation is necessary in this patient group.http://dx.doi.org/10.1155/2011/130574 |
| spellingShingle | Séamus Hussey Rebecca Wall Emma Gruffman Lisa O'Sullivan C. Anthony Ryan Brendan Murphy Gerald Fitzgerald Catherine Stanton R. Paul Ross Parenteral Antibiotics Reduce Bifidobacteria Colonization and Diversity in Neonates International Journal of Microbiology |
| title | Parenteral Antibiotics Reduce Bifidobacteria Colonization and Diversity in Neonates |
| title_full | Parenteral Antibiotics Reduce Bifidobacteria Colonization and Diversity in Neonates |
| title_fullStr | Parenteral Antibiotics Reduce Bifidobacteria Colonization and Diversity in Neonates |
| title_full_unstemmed | Parenteral Antibiotics Reduce Bifidobacteria Colonization and Diversity in Neonates |
| title_short | Parenteral Antibiotics Reduce Bifidobacteria Colonization and Diversity in Neonates |
| title_sort | parenteral antibiotics reduce bifidobacteria colonization and diversity in neonates |
| url | http://dx.doi.org/10.1155/2011/130574 |
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