Human Leukocyte Antigen Diversity: A Southern African Perspective
Despite the increasingly well-documented evidence of high genetic, ethnic, and linguistic diversity amongst African populations, there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA is part of the host defense mechanism mediated through antigen presentation to e...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/746151 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552218138509312 |
|---|---|
| author | Mqondisi Tshabalala Juanita Mellet Michael S. Pepper |
| author_facet | Mqondisi Tshabalala Juanita Mellet Michael S. Pepper |
| author_sort | Mqondisi Tshabalala |
| collection | DOAJ |
| description | Despite the increasingly well-documented evidence of high genetic, ethnic, and linguistic diversity amongst African populations, there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA is part of the host defense mechanism mediated through antigen presentation to effector cells of the immune system. With the high disease burden in southern Africa, HLA diversity data is increasingly important in the design of population-specific vaccines and the improvement of transplantation therapeutic interventions. This review highlights the paucity of HLA diversity data amongst southern African populations and defines a need for information of this kind. This information will support disease association studies, provide guidance in vaccine design, and improve transplantation outcomes. |
| format | Article |
| id | doaj-art-3f7aaf077fd3413fb29051d8790ffae0 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3f7aaf077fd3413fb29051d8790ffae02025-02-03T05:59:17ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/746151746151Human Leukocyte Antigen Diversity: A Southern African PerspectiveMqondisi Tshabalala0Juanita Mellet1Michael S. Pepper2Department of Immunology and Institute for Cellular and Molecular Medicine, Faculty of Health Sciences, University of Pretoria, P.O. Box 2034, Pretoria 0001, South AfricaDepartment of Immunology and Institute for Cellular and Molecular Medicine, Faculty of Health Sciences, University of Pretoria, P.O. Box 2034, Pretoria 0001, South AfricaDepartment of Immunology and Institute for Cellular and Molecular Medicine, Faculty of Health Sciences, University of Pretoria, P.O. Box 2034, Pretoria 0001, South AfricaDespite the increasingly well-documented evidence of high genetic, ethnic, and linguistic diversity amongst African populations, there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA is part of the host defense mechanism mediated through antigen presentation to effector cells of the immune system. With the high disease burden in southern Africa, HLA diversity data is increasingly important in the design of population-specific vaccines and the improvement of transplantation therapeutic interventions. This review highlights the paucity of HLA diversity data amongst southern African populations and defines a need for information of this kind. This information will support disease association studies, provide guidance in vaccine design, and improve transplantation outcomes.http://dx.doi.org/10.1155/2015/746151 |
| spellingShingle | Mqondisi Tshabalala Juanita Mellet Michael S. Pepper Human Leukocyte Antigen Diversity: A Southern African Perspective Journal of Immunology Research |
| title | Human Leukocyte Antigen Diversity: A Southern African Perspective |
| title_full | Human Leukocyte Antigen Diversity: A Southern African Perspective |
| title_fullStr | Human Leukocyte Antigen Diversity: A Southern African Perspective |
| title_full_unstemmed | Human Leukocyte Antigen Diversity: A Southern African Perspective |
| title_short | Human Leukocyte Antigen Diversity: A Southern African Perspective |
| title_sort | human leukocyte antigen diversity a southern african perspective |
| url | http://dx.doi.org/10.1155/2015/746151 |
| work_keys_str_mv | AT mqondisitshabalala humanleukocyteantigendiversityasouthernafricanperspective AT juanitamellet humanleukocyteantigendiversityasouthernafricanperspective AT michaelspepper humanleukocyteantigendiversityasouthernafricanperspective |