Cardiovascular Effects Mediated by HMMR and CD44
Cardiovascular disease (CVD) is the leading cause of death worldwide. The most dangerous life-threatening symptoms of CVD are myocardial infarction and stroke. The causes of CVD are not entirely clear, and new therapeutic targets are still being sought. One of the factors involved in CVD development...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/4977209 |
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| author | Kinga Jaskuła Mariusz Sacharczuk Zbigniew Gaciong Dominik S. Skiba |
| author_facet | Kinga Jaskuła Mariusz Sacharczuk Zbigniew Gaciong Dominik S. Skiba |
| author_sort | Kinga Jaskuła |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is the leading cause of death worldwide. The most dangerous life-threatening symptoms of CVD are myocardial infarction and stroke. The causes of CVD are not entirely clear, and new therapeutic targets are still being sought. One of the factors involved in CVD development among vascular damage and oxidative stress is chronic inflammation. It is known that hyaluronic acid plays an important role in inflammation and is regulated by numerous stimuli, including proinflammatory cytokines. The main receptors for hyaluronic acid are CD44 and RHAMM. These receptors are membrane proteins that differ in structure, but it seems that they can perform similar or synergistic functions in many diseases. Both RHAMM and CD44 are involved in cell migration and wound healing. However, their close association with CVD is not fully understood. In this review, we describe the role of both receptors in CVD. |
| format | Article |
| id | doaj-art-3f7a07482b594ceb8d2751c1c2b6ea29 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3f7a07482b594ceb8d2751c1c2b6ea292025-02-03T07:24:01ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/49772094977209Cardiovascular Effects Mediated by HMMR and CD44Kinga Jaskuła0Mariusz Sacharczuk1Zbigniew Gaciong2Dominik S. Skiba3Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzebiec, PolandDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzebiec, PolandDepartment of Internal Medicine, Hypertension and Vascular Diseases, Medical University of Warsaw, Banacha 1A, Warsaw, PolandDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzebiec, PolandCardiovascular disease (CVD) is the leading cause of death worldwide. The most dangerous life-threatening symptoms of CVD are myocardial infarction and stroke. The causes of CVD are not entirely clear, and new therapeutic targets are still being sought. One of the factors involved in CVD development among vascular damage and oxidative stress is chronic inflammation. It is known that hyaluronic acid plays an important role in inflammation and is regulated by numerous stimuli, including proinflammatory cytokines. The main receptors for hyaluronic acid are CD44 and RHAMM. These receptors are membrane proteins that differ in structure, but it seems that they can perform similar or synergistic functions in many diseases. Both RHAMM and CD44 are involved in cell migration and wound healing. However, their close association with CVD is not fully understood. In this review, we describe the role of both receptors in CVD.http://dx.doi.org/10.1155/2021/4977209 |
| spellingShingle | Kinga Jaskuła Mariusz Sacharczuk Zbigniew Gaciong Dominik S. Skiba Cardiovascular Effects Mediated by HMMR and CD44 Mediators of Inflammation |
| title | Cardiovascular Effects Mediated by HMMR and CD44 |
| title_full | Cardiovascular Effects Mediated by HMMR and CD44 |
| title_fullStr | Cardiovascular Effects Mediated by HMMR and CD44 |
| title_full_unstemmed | Cardiovascular Effects Mediated by HMMR and CD44 |
| title_short | Cardiovascular Effects Mediated by HMMR and CD44 |
| title_sort | cardiovascular effects mediated by hmmr and cd44 |
| url | http://dx.doi.org/10.1155/2021/4977209 |
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