Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update
Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. Studies of the involvement of MMPs in IBD since 2006 have revealed an array...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/964131 |
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| author | Shane O’Sullivan John F. Gilmer Carlos Medina |
| author_facet | Shane O’Sullivan John F. Gilmer Carlos Medina |
| author_sort | Shane O’Sullivan |
| collection | DOAJ |
| description | Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. Studies of the involvement of MMPs in IBD since 2006 have revealed an array of immune and stromal cells which release the proteases in response to inflammatory cytokines and growth factors. Through digestion of the extracellular matrix and cleavage of bioactive proteins, a huge diversity of roles have been revealed for the MMPs in IBD, where they have been shown to regulate epithelial barrier function, immune response, angiogenesis, fibrosis, and wound healing. For this reason, MMPs have been recognised as potential biomarkers for disease activity in IBD and inhibition remains a huge area of interest. This review describes new roles of MMPs in the pathophysiology of IBD and suggests future directions for the development of treatment strategies in this condition. |
| format | Article |
| id | doaj-art-3f79306ace5e404094a1b6636392efa7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3f79306ace5e404094a1b6636392efa72025-02-03T06:14:12ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/964131964131Matrix Metalloproteinases in Inflammatory Bowel Disease: An UpdateShane O’Sullivan0John F. Gilmer1Carlos Medina2School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, IrelandSchool of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, IrelandSchool of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, IrelandMatrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. Studies of the involvement of MMPs in IBD since 2006 have revealed an array of immune and stromal cells which release the proteases in response to inflammatory cytokines and growth factors. Through digestion of the extracellular matrix and cleavage of bioactive proteins, a huge diversity of roles have been revealed for the MMPs in IBD, where they have been shown to regulate epithelial barrier function, immune response, angiogenesis, fibrosis, and wound healing. For this reason, MMPs have been recognised as potential biomarkers for disease activity in IBD and inhibition remains a huge area of interest. This review describes new roles of MMPs in the pathophysiology of IBD and suggests future directions for the development of treatment strategies in this condition.http://dx.doi.org/10.1155/2015/964131 |
| spellingShingle | Shane O’Sullivan John F. Gilmer Carlos Medina Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update Mediators of Inflammation |
| title | Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update |
| title_full | Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update |
| title_fullStr | Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update |
| title_full_unstemmed | Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update |
| title_short | Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update |
| title_sort | matrix metalloproteinases in inflammatory bowel disease an update |
| url | http://dx.doi.org/10.1155/2015/964131 |
| work_keys_str_mv | AT shaneosullivan matrixmetalloproteinasesininflammatoryboweldiseaseanupdate AT johnfgilmer matrixmetalloproteinasesininflammatoryboweldiseaseanupdate AT carlosmedina matrixmetalloproteinasesininflammatoryboweldiseaseanupdate |