Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patients
Abstract Aims Evidence on the association of macrophage‐ and neutrophil‐related blood biomarkers with clinical outcome in heart failure patients is limited, and, with the exception of C‐reactive protein, no data exist on their temporal evolution. We aimed to investigate whether temporal patterns of...
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.12678 |
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| author | Dominika Klimczak‐Tomaniak Elke Bouwens Anne‐Sophie Schuurman K. Martijn Akkerhuis Alina Constantinescu Jasper Brugts B. Daan Westenbrink Jan vanRamshorst Tjeerd Germans Leszek Pączek Victor Umans Eric Boersma Isabella Kardys |
| author_facet | Dominika Klimczak‐Tomaniak Elke Bouwens Anne‐Sophie Schuurman K. Martijn Akkerhuis Alina Constantinescu Jasper Brugts B. Daan Westenbrink Jan vanRamshorst Tjeerd Germans Leszek Pączek Victor Umans Eric Boersma Isabella Kardys |
| author_sort | Dominika Klimczak‐Tomaniak |
| collection | DOAJ |
| description | Abstract Aims Evidence on the association of macrophage‐ and neutrophil‐related blood biomarkers with clinical outcome in heart failure patients is limited, and, with the exception of C‐reactive protein, no data exist on their temporal evolution. We aimed to investigate whether temporal patterns of these biomarkers are related to clinical outcome in patients with stable chronic heart failure (CHF). Methods and Results In 263 patients with CHF, we performed serial plasma measurements of scavenger receptor cysteine‐rich type 1 protein M130 (CD163), tartrate‐resistant acid phosphatase type 5 (TRAP), granulins (GRN), spondin‐1 (SPON1), peptidoglycan recognition protein 1 (PGLYRP1), and tissue factor pathway inhibitor (TFPI). The Cardiovascular Panel III (Olink Proteomics AB, Uppsala, Sweden) was used. During 2.2 years of follow‐up, we collected 1984 samples before the occurrence of the composite primary endpoint (PE) or censoring. For efficiency, we selected 567 samples for the measurements (all baseline samples, the last two samples preceding the PE, and the last sample before censoring in event‐free patients). The relationship between repeatedly measured biomarker levels and the PE was evaluated by joint models. Mean (±standard deviation) age was 67 ± 13 years; 189 (72%) were men; left ventricular ejection fraction (%) was 32 ± 11. During follow‐up, 70 (27%) patients experienced the PE. Serially measured biomarkers predicted the PE in a multivariable model adjusted for baseline clinical characteristics [hazard ratio (95% confidence interval) per 1‐standard deviation change in biomarker]: CD163 [2.07(1.47–2.98), P < 0.001], TRAP [0.62 (0.43–0.90), P = 0.009], GRN [2.46 (1.64–3.84), P < 0.001], SPON1 [3.94 (2.50–6.50), P < 0.001], and PGLYRP1 [1.62 (1.14–2.31), P = 0.006]. Conclusions Changes in plasma levels of CD163, TRAP, GRN, SPON1, and PGLYRP1 precede adverse cardiovascular events in patients with CHF. |
| format | Article |
| id | doaj-art-3f632ab400da4cda8948b6e226494fae |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-3f632ab400da4cda8948b6e226494fae2025-02-03T10:25:46ZengWileyESC Heart Failure2055-58222020-06-01731190120010.1002/ehf2.12678Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patientsDominika Klimczak‐Tomaniak0Elke Bouwens1Anne‐Sophie Schuurman2K. Martijn Akkerhuis3Alina Constantinescu4Jasper Brugts5B. Daan Westenbrink6Jan vanRamshorst7Tjeerd Germans8Leszek Pączek9Victor Umans10Eric Boersma11Isabella Kardys12Department of Cardiology Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsDepartment of Cardiology Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsDepartment of Cardiology Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsDepartment of Cardiology Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsDepartment of Cardiology Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsDepartment of Cardiology Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsDepartment of Cardiology, University Medical Center Groningen University of Groningen Groningen The NetherlandsDepartment of Cardiology Northwest Clinics Alkmaar The NetherlandsDepartment of Cardiology Northwest Clinics Alkmaar The NetherlandsDepartment of Immunology, Transplantation and Internal Medicine Medical University of Warsaw Warsaw PolandDepartment of Cardiology Northwest Clinics Alkmaar The NetherlandsDepartment of Cardiology Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsDepartment of Cardiology Erasmus MC, University Medical Center Rotterdam Rotterdam The NetherlandsAbstract Aims Evidence on the association of macrophage‐ and neutrophil‐related blood biomarkers with clinical outcome in heart failure patients is limited, and, with the exception of C‐reactive protein, no data exist on their temporal evolution. We aimed to investigate whether temporal patterns of these biomarkers are related to clinical outcome in patients with stable chronic heart failure (CHF). Methods and Results In 263 patients with CHF, we performed serial plasma measurements of scavenger receptor cysteine‐rich type 1 protein M130 (CD163), tartrate‐resistant acid phosphatase type 5 (TRAP), granulins (GRN), spondin‐1 (SPON1), peptidoglycan recognition protein 1 (PGLYRP1), and tissue factor pathway inhibitor (TFPI). The Cardiovascular Panel III (Olink Proteomics AB, Uppsala, Sweden) was used. During 2.2 years of follow‐up, we collected 1984 samples before the occurrence of the composite primary endpoint (PE) or censoring. For efficiency, we selected 567 samples for the measurements (all baseline samples, the last two samples preceding the PE, and the last sample before censoring in event‐free patients). The relationship between repeatedly measured biomarker levels and the PE was evaluated by joint models. Mean (±standard deviation) age was 67 ± 13 years; 189 (72%) were men; left ventricular ejection fraction (%) was 32 ± 11. During follow‐up, 70 (27%) patients experienced the PE. Serially measured biomarkers predicted the PE in a multivariable model adjusted for baseline clinical characteristics [hazard ratio (95% confidence interval) per 1‐standard deviation change in biomarker]: CD163 [2.07(1.47–2.98), P < 0.001], TRAP [0.62 (0.43–0.90), P = 0.009], GRN [2.46 (1.64–3.84), P < 0.001], SPON1 [3.94 (2.50–6.50), P < 0.001], and PGLYRP1 [1.62 (1.14–2.31), P = 0.006]. Conclusions Changes in plasma levels of CD163, TRAP, GRN, SPON1, and PGLYRP1 precede adverse cardiovascular events in patients with CHF.https://doi.org/10.1002/ehf2.12678Scavenger receptor cysteine‐rich type 1 protein M130Tartrate‐resistant acid phosphatase type 5GranulinsSpondin‐1Peptidoglycan recognition protein |
| spellingShingle | Dominika Klimczak‐Tomaniak Elke Bouwens Anne‐Sophie Schuurman K. Martijn Akkerhuis Alina Constantinescu Jasper Brugts B. Daan Westenbrink Jan vanRamshorst Tjeerd Germans Leszek Pączek Victor Umans Eric Boersma Isabella Kardys Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patients ESC Heart Failure Scavenger receptor cysteine‐rich type 1 protein M130 Tartrate‐resistant acid phosphatase type 5 Granulins Spondin‐1 Peptidoglycan recognition protein |
| title | Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patients |
| title_full | Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patients |
| title_fullStr | Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patients |
| title_full_unstemmed | Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patients |
| title_short | Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patients |
| title_sort | temporal patterns of macrophage and neutrophil related markers are associated with clinical outcome in heart failure patients |
| topic | Scavenger receptor cysteine‐rich type 1 protein M130 Tartrate‐resistant acid phosphatase type 5 Granulins Spondin‐1 Peptidoglycan recognition protein |
| url | https://doi.org/10.1002/ehf2.12678 |
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