The prevalence of CYP2D6*10 (100C>T, rs1065852) gene polymorphism in Russian patients with epilepsy (North-Western and Siberian Districts)
The gene CYP2D6 is of great interest also due to its highly polymorphic nature and involvement in a high number of medication metabolisms. The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. Th...
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/319 |
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| author | N. A. Sivakova N. A. Shnayder D. V. Dmitrenko L. V. Lipatova M. Y. Tolmachev R. F. Nasyrova |
| author_facet | N. A. Sivakova N. A. Shnayder D. V. Dmitrenko L. V. Lipatova M. Y. Tolmachev R. F. Nasyrova |
| author_sort | N. A. Sivakova |
| collection | DOAJ |
| description | The gene CYP2D6 is of great interest also due to its highly polymorphic nature and involvement in a high number of medication metabolisms. The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. The purpose of this study was to investigate of CYP2D6*10 polymorphism prevalence in patients with epilepsy in the North-West and the Siberian region of the Russia. The results of the study showed differences in the prevalence of alleles responsible for “intermediate” metabolites in the North-West and Siberian regions of Russia were identified, it’s may be associated with genetic drift and accumulation of alleles typical for European and Asian populations. |
| format | Article |
| id | doaj-art-3f5b030a5e554e9b87cb13038e54a60c |
| institution | Kabale University |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-3f5b030a5e554e9b87cb13038e54a60c2025-08-20T03:42:06ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2019-12-0104-1919210.31363/2313-7053-2019-4-1-91-92298The prevalence of CYP2D6*10 (100C>T, rs1065852) gene polymorphism in Russian patients with epilepsy (North-Western and Siberian Districts)N. A. Sivakova0N. A. Shnayder1D. V. Dmitrenko2L. V. Lipatova3M. Y. Tolmachev4R. F. Nasyrova5V.M. Bekhterev National Research Medical Centre for Psychiatry and NeurologyV.M. Bekhterev National Research Medical Centre for Psychiatry and NeurologyV.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Department of Medical Genetics and Clinical NeurophysiologyAlmazov National Medical Research Centre, Saint-Petersburg, Russia, Department of Neurology and PsychiatryV.M. Bekhterev National Research Medical Centre for Psychiatry and NeurologyV.M. Bekhterev National Research Medical Centre for Psychiatry and NeurologyThe gene CYP2D6 is of great interest also due to its highly polymorphic nature and involvement in a high number of medication metabolisms. The presence of polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. The purpose of this study was to investigate of CYP2D6*10 polymorphism prevalence in patients with epilepsy in the North-West and the Siberian region of the Russia. The results of the study showed differences in the prevalence of alleles responsible for “intermediate” metabolites in the North-West and Siberian regions of Russia were identified, it’s may be associated with genetic drift and accumulation of alleles typical for European and Asian populations.https://www.bekhterevreview.com/jour/article/view/319pharmacogenetics, epilepsy, cyp2d6, cyp2d6*10, rs1065852 |
| spellingShingle | N. A. Sivakova N. A. Shnayder D. V. Dmitrenko L. V. Lipatova M. Y. Tolmachev R. F. Nasyrova The prevalence of CYP2D6*10 (100C>T, rs1065852) gene polymorphism in Russian patients with epilepsy (North-Western and Siberian Districts) Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева pharmacogenetics, epilepsy, cyp2d6, cyp2d6*10, rs1065852 |
| title | The prevalence of CYP2D6*10 (100C>T, rs1065852) gene polymorphism in Russian patients with epilepsy (North-Western and Siberian Districts) |
| title_full | The prevalence of CYP2D6*10 (100C>T, rs1065852) gene polymorphism in Russian patients with epilepsy (North-Western and Siberian Districts) |
| title_fullStr | The prevalence of CYP2D6*10 (100C>T, rs1065852) gene polymorphism in Russian patients with epilepsy (North-Western and Siberian Districts) |
| title_full_unstemmed | The prevalence of CYP2D6*10 (100C>T, rs1065852) gene polymorphism in Russian patients with epilepsy (North-Western and Siberian Districts) |
| title_short | The prevalence of CYP2D6*10 (100C>T, rs1065852) gene polymorphism in Russian patients with epilepsy (North-Western and Siberian Districts) |
| title_sort | prevalence of cyp2d6 10 100c t rs1065852 gene polymorphism in russian patients with epilepsy north western and siberian districts |
| topic | pharmacogenetics, epilepsy, cyp2d6, cyp2d6*10, rs1065852 |
| url | https://www.bekhterevreview.com/jour/article/view/319 |
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