Metabolic activities are selective modulators for individual segmentation clock processes
Abstract Numerous cellular and molecular processes during embryonic development prompt the fundamental question of how their tempos are coordinated and whether a common global modulator exists. While the segmentation clock tempo scales with the kinetics of gene expression and degradation processes o...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56120-5 |
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| _version_ | 1832585558643179520 |
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| author | Mitsuhiro Matsuda Jorge Lázaro Miki Ebisuya |
| author_facet | Mitsuhiro Matsuda Jorge Lázaro Miki Ebisuya |
| author_sort | Mitsuhiro Matsuda |
| collection | DOAJ |
| description | Abstract Numerous cellular and molecular processes during embryonic development prompt the fundamental question of how their tempos are coordinated and whether a common global modulator exists. While the segmentation clock tempo scales with the kinetics of gene expression and degradation processes of the core clock gene Hes7 across mammals, the coordination of these processes remains unclear. This study examines whether metabolic activities serve as a global modulator for the segmentation clock, finding them to be selective instead. Several metabolic inhibitions extend the clock period but affect key processes differently: glycolysis inhibition slows Hes7 protein degradation and production delay without altering intron delay, while electron transport chain inhibition extends intron delay without influencing the other processes. Combinations of distinct metabolic inhibitions exhibit synergistic effects. We propose that the scaled kinetics of segmentation clock processes across species may result from combined selective modulators shaped by evolutionary constraints, rather than a single global modulator. |
| format | Article |
| id | doaj-art-3f5ae8115d94411a863cba5a30147556 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-3f5ae8115d94411a863cba5a301475562025-01-26T12:41:43ZengNature PortfolioNature Communications2041-17232025-01-0116111310.1038/s41467-025-56120-5Metabolic activities are selective modulators for individual segmentation clock processesMitsuhiro Matsuda0Jorge Lázaro1Miki Ebisuya2European Molecular Biology Laboratory (EMBL) BarcelonaEuropean Molecular Biology Laboratory (EMBL) BarcelonaEuropean Molecular Biology Laboratory (EMBL) BarcelonaAbstract Numerous cellular and molecular processes during embryonic development prompt the fundamental question of how their tempos are coordinated and whether a common global modulator exists. While the segmentation clock tempo scales with the kinetics of gene expression and degradation processes of the core clock gene Hes7 across mammals, the coordination of these processes remains unclear. This study examines whether metabolic activities serve as a global modulator for the segmentation clock, finding them to be selective instead. Several metabolic inhibitions extend the clock period but affect key processes differently: glycolysis inhibition slows Hes7 protein degradation and production delay without altering intron delay, while electron transport chain inhibition extends intron delay without influencing the other processes. Combinations of distinct metabolic inhibitions exhibit synergistic effects. We propose that the scaled kinetics of segmentation clock processes across species may result from combined selective modulators shaped by evolutionary constraints, rather than a single global modulator.https://doi.org/10.1038/s41467-025-56120-5 |
| spellingShingle | Mitsuhiro Matsuda Jorge Lázaro Miki Ebisuya Metabolic activities are selective modulators for individual segmentation clock processes Nature Communications |
| title | Metabolic activities are selective modulators for individual segmentation clock processes |
| title_full | Metabolic activities are selective modulators for individual segmentation clock processes |
| title_fullStr | Metabolic activities are selective modulators for individual segmentation clock processes |
| title_full_unstemmed | Metabolic activities are selective modulators for individual segmentation clock processes |
| title_short | Metabolic activities are selective modulators for individual segmentation clock processes |
| title_sort | metabolic activities are selective modulators for individual segmentation clock processes |
| url | https://doi.org/10.1038/s41467-025-56120-5 |
| work_keys_str_mv | AT mitsuhiromatsuda metabolicactivitiesareselectivemodulatorsforindividualsegmentationclockprocesses AT jorgelazaro metabolicactivitiesareselectivemodulatorsforindividualsegmentationclockprocesses AT mikiebisuya metabolicactivitiesareselectivemodulatorsforindividualsegmentationclockprocesses |