Angioedema due to enalapril. A case report
Angiotensin converting enzyme inhibitors are used by more than 40 million people worldwide for the treatment of cardiovascular diseases. They are considered safe, although they can cause severe angioedema in 0.1 to 0.5% of patients. The case of a 67-years-old male patient diagnosed with diabetes mel...
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| Format: | Article |
| Language: | Spanish |
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Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2023-07-01
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| Series: | Medisur |
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| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/5639 |
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| author | Belkis Barrios Romero Ana María Ramos Cedeño Yeny Dueñas Pérez Mirtha Amarilis Hernández López |
| author_facet | Belkis Barrios Romero Ana María Ramos Cedeño Yeny Dueñas Pérez Mirtha Amarilis Hernández López |
| author_sort | Belkis Barrios Romero |
| collection | DOAJ |
| description | Angiotensin converting enzyme inhibitors are used by more than 40 million people worldwide for the treatment of cardiovascular diseases. They are considered safe, although they can cause severe angioedema in 0.1 to 0.5% of patients. The case of a 67-years-old male patient diagnosed with diabetes mellitus and arterial hypertension, treated with metformin, hydrochlorothiazide and enalapril for approximately four years, who was admitted to the emergency room with severe edema of the third anterior of the tongue, without respiratory compromise is presented. Hydrocortisone and diphenhydramine were indicated and he evolved satisfactorily, for which he was discharged and prednisone and diphenhydramine were prescribed orally; he discontinued enlapril, 48 hours later he was reassessed and was asymptomatic. The mechanism by which these drugs produce angioedema is not clear, but it would probably be due to the tissue accumulation of bradykinin and can occur at any time during treatment. The correct history, early diagnosis and immediate treatment with intravenous hydrocortisone are aspects to consider in similar cases. Analysis of the event through pharmacovigilance allowed it to be classified as severe, probably related to the enalapril consumption. This generates alerts to inform health staff and make decisions related to medications, which allow immediate action in order to reduce morbidity and mortality. |
| format | Article |
| id | doaj-art-3f48ec3f2b9948acba1a8cb2cc96bdd6 |
| institution | Kabale University |
| issn | 1727-897X |
| language | Spanish |
| publishDate | 2023-07-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj-art-3f48ec3f2b9948acba1a8cb2cc96bdd62025-01-30T21:29:00ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2023-07-012148969022316Angioedema due to enalapril. A case reportBelkis Barrios Romero0Ana María Ramos Cedeño1Yeny Dueñas Pérez2Mirtha Amarilis Hernández López3Universidad de Ciencias Médicas de Cienfuegos. Cuba.Universidad de Ciencias Médicas de Cienfuegos. Cuba.Universidad de Ciencias Médicas de Cienfuegos. Cuba.Universidad de Ciencias Médicas de Cienfuegos. Cuba.Angiotensin converting enzyme inhibitors are used by more than 40 million people worldwide for the treatment of cardiovascular diseases. They are considered safe, although they can cause severe angioedema in 0.1 to 0.5% of patients. The case of a 67-years-old male patient diagnosed with diabetes mellitus and arterial hypertension, treated with metformin, hydrochlorothiazide and enalapril for approximately four years, who was admitted to the emergency room with severe edema of the third anterior of the tongue, without respiratory compromise is presented. Hydrocortisone and diphenhydramine were indicated and he evolved satisfactorily, for which he was discharged and prednisone and diphenhydramine were prescribed orally; he discontinued enlapril, 48 hours later he was reassessed and was asymptomatic. The mechanism by which these drugs produce angioedema is not clear, but it would probably be due to the tissue accumulation of bradykinin and can occur at any time during treatment. The correct history, early diagnosis and immediate treatment with intravenous hydrocortisone are aspects to consider in similar cases. Analysis of the event through pharmacovigilance allowed it to be classified as severe, probably related to the enalapril consumption. This generates alerts to inform health staff and make decisions related to medications, which allow immediate action in order to reduce morbidity and mortality.http://medisur.sld.cu/index.php/medisur/article/view/5639inhibidores de la enzima convertidora de angiotensinaenalapril, inflamaciónedemareporte de casos |
| spellingShingle | Belkis Barrios Romero Ana María Ramos Cedeño Yeny Dueñas Pérez Mirtha Amarilis Hernández López Angioedema due to enalapril. A case report Medisur inhibidores de la enzima convertidora de angiotensina enalapril, inflamación edema reporte de casos |
| title | Angioedema due to enalapril. A case report |
| title_full | Angioedema due to enalapril. A case report |
| title_fullStr | Angioedema due to enalapril. A case report |
| title_full_unstemmed | Angioedema due to enalapril. A case report |
| title_short | Angioedema due to enalapril. A case report |
| title_sort | angioedema due to enalapril a case report |
| topic | inhibidores de la enzima convertidora de angiotensina enalapril, inflamación edema reporte de casos |
| url | http://medisur.sld.cu/index.php/medisur/article/view/5639 |
| work_keys_str_mv | AT belkisbarriosromero angioedemaduetoenalaprilacasereport AT anamariaramoscedeno angioedemaduetoenalaprilacasereport AT yenyduenasperez angioedemaduetoenalaprilacasereport AT mirthaamarilishernandezlopez angioedemaduetoenalaprilacasereport |