Invalidity of SUV Measurements of Lesions in Close Proximity to Hot Sources due to “Shine-Through” Effect on FDG PET-CT Interpretation
It is well known that many technical and physiologic factors can affect the reliability of the standardized uptake value (SUV) on FDG PET-CT. Another potential problem of which we may be aware but has not been previously discussed is significant SUV overestimation of lesions in the direct neighborho...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Radiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/867218 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565224375320576 |
|---|---|
| author | Yiyan Liu |
| author_facet | Yiyan Liu |
| author_sort | Yiyan Liu |
| collection | DOAJ |
| description | It is well known that many technical and physiologic factors can affect the reliability of the standardized uptake value (SUV) on FDG PET-CT. Another potential problem of which we may be aware but has not been previously discussed is significant SUV overestimation of lesions in the direct neighborhood of large hot sources, namely, areas with high FDG uptake or activity such as a tumor, myocardium, urinary bladder, kidney, or gastrointestinal tract. The magnitude of SUV overestimation of the lesions directly neighboring the large hot sources is varied among the different cases, and it is possibly secondary to “shine-through” effect of the hot sources, which would warrant further systematic investigation such as phantom simulation experiment. If the lesion is in the close territory of the hot source, measured SUV is often overestimated and invalid. Visual interpretation should be used for evaluation of FDG avidity of the lesion. |
| format | Article |
| id | doaj-art-3f45286ee9624417be358cfe4d35a459 |
| institution | Kabale University |
| issn | 2090-1941 2090-195X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Radiology Research and Practice |
| spelling | doaj-art-3f45286ee9624417be358cfe4d35a4592025-02-03T01:08:53ZengWileyRadiology Research and Practice2090-19412090-195X2012-01-01201210.1155/2012/867218867218Invalidity of SUV Measurements of Lesions in Close Proximity to Hot Sources due to “Shine-Through” Effect on FDG PET-CT InterpretationYiyan Liu0Nuclear Medicine Service, Department of Radiology, New Jersey Medical School, 150 Bergen Street, H-141, Newark, NJ 07103, USAIt is well known that many technical and physiologic factors can affect the reliability of the standardized uptake value (SUV) on FDG PET-CT. Another potential problem of which we may be aware but has not been previously discussed is significant SUV overestimation of lesions in the direct neighborhood of large hot sources, namely, areas with high FDG uptake or activity such as a tumor, myocardium, urinary bladder, kidney, or gastrointestinal tract. The magnitude of SUV overestimation of the lesions directly neighboring the large hot sources is varied among the different cases, and it is possibly secondary to “shine-through” effect of the hot sources, which would warrant further systematic investigation such as phantom simulation experiment. If the lesion is in the close territory of the hot source, measured SUV is often overestimated and invalid. Visual interpretation should be used for evaluation of FDG avidity of the lesion.http://dx.doi.org/10.1155/2012/867218 |
| spellingShingle | Yiyan Liu Invalidity of SUV Measurements of Lesions in Close Proximity to Hot Sources due to “Shine-Through” Effect on FDG PET-CT Interpretation Radiology Research and Practice |
| title | Invalidity of SUV Measurements of Lesions in Close Proximity to Hot Sources due to “Shine-Through” Effect on FDG PET-CT Interpretation |
| title_full | Invalidity of SUV Measurements of Lesions in Close Proximity to Hot Sources due to “Shine-Through” Effect on FDG PET-CT Interpretation |
| title_fullStr | Invalidity of SUV Measurements of Lesions in Close Proximity to Hot Sources due to “Shine-Through” Effect on FDG PET-CT Interpretation |
| title_full_unstemmed | Invalidity of SUV Measurements of Lesions in Close Proximity to Hot Sources due to “Shine-Through” Effect on FDG PET-CT Interpretation |
| title_short | Invalidity of SUV Measurements of Lesions in Close Proximity to Hot Sources due to “Shine-Through” Effect on FDG PET-CT Interpretation |
| title_sort | invalidity of suv measurements of lesions in close proximity to hot sources due to shine through effect on fdg pet ct interpretation |
| url | http://dx.doi.org/10.1155/2012/867218 |
| work_keys_str_mv | AT yiyanliu invalidityofsuvmeasurementsoflesionsincloseproximitytohotsourcesduetoshinethrougheffectonfdgpetctinterpretation |