Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity
Phospholipases A2 (PLA2s) represent one of the largest groups of lipid-modifying enzymes. Over the years, significant advances have been made in understanding their potential physiological and pathological functions. Depending on their calcium requirement for activation, PLA2s are classified into ca...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/569149 |
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| author | Julie Allyson Xiaoning Bi Michel Baudry Guy Massicotte |
| author_facet | Julie Allyson Xiaoning Bi Michel Baudry Guy Massicotte |
| author_sort | Julie Allyson |
| collection | DOAJ |
| description | Phospholipases A2 (PLA2s) represent one of the largest groups of lipid-modifying enzymes. Over the years, significant advances have been made in understanding their potential physiological and pathological functions. Depending on their calcium requirement for activation, PLA2s are classified into calcium dependent and independent. This paper mainly focuses on brain calcium-independent PLA2 (iPLA2) and on the mechanisms by which they influence neuronal function and regulate synaptic plasticity. Particular attention will be given to the iPLA2γ isoform and its role in the regulation of synaptic glutamate receptors. In particular, the paper discusses the possibility that brain iPLA2γ deficiencies could destabilise normal synaptic operation and might contribute to the aetiology of some brain disorders. In this line, the paper presents new data indicating that iPLA2γ deficiencies accentuate AMPA receptor destabilization and tau phosphorylation, which suggests that this iPLA2 isoform should be considered as a potential target for the treatment of Tau-related disorders. |
| format | Article |
| id | doaj-art-3f43c8aaf97d4903ada2e4fe778f217e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3f43c8aaf97d4903ada2e4fe778f217e2025-02-03T06:04:58ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/569149569149Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 ActivityJulie Allyson0Xiaoning Bi1Michel Baudry2Guy Massicotte3Département de Chimie-Biologie, Université du Québec à Trois-Rivières, 3351 Boulevard des Forges, QC, G9A 5H7, CanadaGraduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766-1854, USAGraduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766-1854, USADépartement de Chimie-Biologie, Université du Québec à Trois-Rivières, 3351 Boulevard des Forges, QC, G9A 5H7, CanadaPhospholipases A2 (PLA2s) represent one of the largest groups of lipid-modifying enzymes. Over the years, significant advances have been made in understanding their potential physiological and pathological functions. Depending on their calcium requirement for activation, PLA2s are classified into calcium dependent and independent. This paper mainly focuses on brain calcium-independent PLA2 (iPLA2) and on the mechanisms by which they influence neuronal function and regulate synaptic plasticity. Particular attention will be given to the iPLA2γ isoform and its role in the regulation of synaptic glutamate receptors. In particular, the paper discusses the possibility that brain iPLA2γ deficiencies could destabilise normal synaptic operation and might contribute to the aetiology of some brain disorders. In this line, the paper presents new data indicating that iPLA2γ deficiencies accentuate AMPA receptor destabilization and tau phosphorylation, which suggests that this iPLA2 isoform should be considered as a potential target for the treatment of Tau-related disorders.http://dx.doi.org/10.1155/2012/569149 |
| spellingShingle | Julie Allyson Xiaoning Bi Michel Baudry Guy Massicotte Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity Neural Plasticity |
| title | Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity |
| title_full | Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity |
| title_fullStr | Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity |
| title_full_unstemmed | Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity |
| title_short | Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity |
| title_sort | maintenance of synaptic stability requires calcium independent phospholipase a2 activity |
| url | http://dx.doi.org/10.1155/2012/569149 |
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