Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review
Myxedema coma is a rare life-threatening form of hypothyroidism that manifests as neuropsychiatric, metabolic, respiratory, and cardiovascular dysfunction. From 2010 to 2022, our hospital managed three cases of myxedema coma. While the overall characteristics of these cases were similar to those in...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2024/2524019 |
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| author | Yosuke Okuno Kosuke Mukai Yuri Tamura Tomoaki Hayakawa Atsunori Fukuhara Iichiro Shimomura |
| author_facet | Yosuke Okuno Kosuke Mukai Yuri Tamura Tomoaki Hayakawa Atsunori Fukuhara Iichiro Shimomura |
| author_sort | Yosuke Okuno |
| collection | DOAJ |
| description | Myxedema coma is a rare life-threatening form of hypothyroidism that manifests as neuropsychiatric, metabolic, respiratory, and cardiovascular dysfunction. From 2010 to 2022, our hospital managed three cases of myxedema coma. While the overall characteristics of these cases were similar to those in previous reports, we noticed that all cases were negative for thyroid autoantibodies and an autopsy in one of the cases exhibited end-stage thyroiditis. During a systematic review of cases from 1999 to 2022, we also noticed that a significant proportion of myxedema coma was caused by seronegative primary hypothyroidism especially in Japan. |
| format | Article |
| id | doaj-art-3f42caccad424e209337523956b02dd5 |
| institution | Kabale University |
| issn | 2090-651X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-3f42caccad424e209337523956b02dd52025-02-03T05:32:40ZengWileyCase Reports in Endocrinology2090-651X2024-01-01202410.1155/2024/2524019Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic ReviewYosuke Okuno0Kosuke Mukai1Yuri Tamura2Tomoaki Hayakawa3Atsunori Fukuhara4Iichiro Shimomura5Department of Metabolic MedicineDepartment of Metabolic MedicineDepartment of Metabolic MedicineDepartment of Metabolic MedicineDepartment of Metabolic MedicineDepartment of Metabolic MedicineMyxedema coma is a rare life-threatening form of hypothyroidism that manifests as neuropsychiatric, metabolic, respiratory, and cardiovascular dysfunction. From 2010 to 2022, our hospital managed three cases of myxedema coma. While the overall characteristics of these cases were similar to those in previous reports, we noticed that all cases were negative for thyroid autoantibodies and an autopsy in one of the cases exhibited end-stage thyroiditis. During a systematic review of cases from 1999 to 2022, we also noticed that a significant proportion of myxedema coma was caused by seronegative primary hypothyroidism especially in Japan.http://dx.doi.org/10.1155/2024/2524019 |
| spellingShingle | Yosuke Okuno Kosuke Mukai Yuri Tamura Tomoaki Hayakawa Atsunori Fukuhara Iichiro Shimomura Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review Case Reports in Endocrinology |
| title | Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review |
| title_full | Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review |
| title_fullStr | Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review |
| title_full_unstemmed | Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review |
| title_short | Frequent Seronegative Primary Hypothyroidism in Myxedema Coma in Japan: Three Case Reports With a Systematic Review |
| title_sort | frequent seronegative primary hypothyroidism in myxedema coma in japan three case reports with a systematic review |
| url | http://dx.doi.org/10.1155/2024/2524019 |
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