Mendelian randomization analysis does not support a causal influence between lipoprotein(A) and immune-mediated inflammatory diseases

Mendelian randomization analysis does not support a causal influence between lipoprotein(A) and immune-mediated inflammatory diseases

Abstract Observational studies have reported an association between lipoprotein(a) (Lp(a)) and immune-mediated inflammatory diseases (IMIDs). This study used Mendelian Randomization (MR) and multivariable MR (MVMR) to explore the causal relationship between lipoprotein(a) [Lp(a)] and immune-mediated...

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Bibliographic Details
Main Authors: Yun Ti, Dan Xu, Xiaoning Qin, Yang Hu, Yuru Xu, Qingzhao Zhao, Peili Bu, Jingyuan Li
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Lipoprotein(a)
Immune-mediated inflammatory diseases
Mendelian randomization analysis
Lipid traits
Multivariable MR analysis
Online Access:https://doi.org/10.1038/s41598-025-88375-9
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