The prevalence of thiamine deficiency among elderly nursing home residents: A cross‐sectional study
Abstract Background Although thiamine deficiency (TD) can lead to Wernicke encephalopathy, the characteristics associated with TD in the elderly have not yet been clarified. We sought to clarify the frequency of TD among an institutionalized elderly population with a controlled dietary intake and to...
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Journal of General and Family Medicine |
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| Online Access: | https://doi.org/10.1002/jgf2.609 |
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| author | Nozomu Uchida Mayumi Ishida Izumi Sato Akira Yoshioka Takao Takahashi Daisuke Furuya Yasuhiro Ebihara Hiroshi Ito Hideki Onishi |
| author_facet | Nozomu Uchida Mayumi Ishida Izumi Sato Akira Yoshioka Takao Takahashi Daisuke Furuya Yasuhiro Ebihara Hiroshi Ito Hideki Onishi |
| author_sort | Nozomu Uchida |
| collection | DOAJ |
| description | Abstract Background Although thiamine deficiency (TD) can lead to Wernicke encephalopathy, the characteristics associated with TD in the elderly have not yet been clarified. We sought to clarify the frequency of TD among an institutionalized elderly population with a controlled dietary intake and to identify possible factors related to TD. Method We undertook a cross‐sectional study of residents in three nursing homes for the elderly as of June 2020. Blood thiamine concentrations were measured using a high‐performance liquid chromatography method, with TD defined as a concentration of <21.3 ng/mL. Basic data (age, sex, height, weight, and BMI), dietary intake for the previous 3 weeks, degree of care (DOC), degree of independence in daily life for elderly with dementia (DIDLED), and comorbidities were analyzed using descriptive statistical methods. Results The mean age (±SD) was 86.9 years (±8.29), with 84 residents (70.0%) being female. The DIDLED varied from total independence to long‐term care level 5 (full assistance), with 89.2% suffering dementia. The mean whole blood thiamine value was 36.18 (±17.58) ng/ml, with TD confirmed in 7 (5.8%) of the 120 residents. All TD patients suffered from dementia. No TD was observed in patients with a near‐normal food intake, and no related factors were observed among the other items. Conclusion Reduced food intake may at increase the risk of TD and symptoms of TD may be overlooked in those displaying symptoms of dementia; thus, it is important for clinicians working with the elderly to remain aware of the potential for TD. |
| format | Article |
| id | doaj-art-3f416f79f4234b7f87aeb82649466668 |
| institution | Kabale University |
| issn | 2189-7948 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of General and Family Medicine |
| spelling | doaj-art-3f416f79f4234b7f87aeb826494666682025-01-28T12:00:52ZengWileyJournal of General and Family Medicine2189-79482023-05-0124314815310.1002/jgf2.609The prevalence of thiamine deficiency among elderly nursing home residents: A cross‐sectional studyNozomu Uchida0Mayumi Ishida1Izumi Sato2Akira Yoshioka3Takao Takahashi4Daisuke Furuya5Yasuhiro Ebihara6Hiroshi Ito7Hideki Onishi8Department of General Medicine Ogano Town Central Hospital Saitama JapanDepartment of Psycho‐oncology Saitama Medical University International Medical Center Saitama JapanDepartment of Clinical Epidemiology, Graduate School of Biomedical Sciences Nagasaki University Nagasaki JapanDepartment of Medical Oncology and Palliative Care Mitsubishi Kyoto Hospital Kyoto JapanDepartment of Supportive Medicine Saitama Medical University International Medical Center Saitama JapanDepartment of General Medicine Saitama Medical University International Medical Center Saitama JapanDepartment of Laboratory Medicine Saitama Medical University International Medical Center Saitama JapanIto Internal Medicine and Pediatric Clinic Fukuoka JapanDepartment of Psycho‐oncology Saitama Medical University International Medical Center Saitama JapanAbstract Background Although thiamine deficiency (TD) can lead to Wernicke encephalopathy, the characteristics associated with TD in the elderly have not yet been clarified. We sought to clarify the frequency of TD among an institutionalized elderly population with a controlled dietary intake and to identify possible factors related to TD. Method We undertook a cross‐sectional study of residents in three nursing homes for the elderly as of June 2020. Blood thiamine concentrations were measured using a high‐performance liquid chromatography method, with TD defined as a concentration of <21.3 ng/mL. Basic data (age, sex, height, weight, and BMI), dietary intake for the previous 3 weeks, degree of care (DOC), degree of independence in daily life for elderly with dementia (DIDLED), and comorbidities were analyzed using descriptive statistical methods. Results The mean age (±SD) was 86.9 years (±8.29), with 84 residents (70.0%) being female. The DIDLED varied from total independence to long‐term care level 5 (full assistance), with 89.2% suffering dementia. The mean whole blood thiamine value was 36.18 (±17.58) ng/ml, with TD confirmed in 7 (5.8%) of the 120 residents. All TD patients suffered from dementia. No TD was observed in patients with a near‐normal food intake, and no related factors were observed among the other items. Conclusion Reduced food intake may at increase the risk of TD and symptoms of TD may be overlooked in those displaying symptoms of dementia; thus, it is important for clinicians working with the elderly to remain aware of the potential for TD.https://doi.org/10.1002/jgf2.609elderlynursing homethiamine deficiencyWernicke encephalopathy |
| spellingShingle | Nozomu Uchida Mayumi Ishida Izumi Sato Akira Yoshioka Takao Takahashi Daisuke Furuya Yasuhiro Ebihara Hiroshi Ito Hideki Onishi The prevalence of thiamine deficiency among elderly nursing home residents: A cross‐sectional study Journal of General and Family Medicine elderly nursing home thiamine deficiency Wernicke encephalopathy |
| title | The prevalence of thiamine deficiency among elderly nursing home residents: A cross‐sectional study |
| title_full | The prevalence of thiamine deficiency among elderly nursing home residents: A cross‐sectional study |
| title_fullStr | The prevalence of thiamine deficiency among elderly nursing home residents: A cross‐sectional study |
| title_full_unstemmed | The prevalence of thiamine deficiency among elderly nursing home residents: A cross‐sectional study |
| title_short | The prevalence of thiamine deficiency among elderly nursing home residents: A cross‐sectional study |
| title_sort | prevalence of thiamine deficiency among elderly nursing home residents a cross sectional study |
| topic | elderly nursing home thiamine deficiency Wernicke encephalopathy |
| url | https://doi.org/10.1002/jgf2.609 |
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