The role of sleep in Alzheimer’s disease: a mini review

Sleep is a stereotyped and well-preserved series of neurophysiological states that are essential for overall health and brain functioning. Emerging research suggests that sleep disturbances are not only associated with but also causally contribute to neurodegenerative disease onset and progression....

Full description

Saved in:
Bibliographic Details
Main Authors: Jay Pathmanathan, M. Brandon Westover, Sudhir Sivakumaran, Jacob Donoghue, Corey B. Puryear
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1428733/full
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832539885673644032
author Jay Pathmanathan
M. Brandon Westover
Sudhir Sivakumaran
Jacob Donoghue
Corey B. Puryear
author_facet Jay Pathmanathan
M. Brandon Westover
Sudhir Sivakumaran
Jacob Donoghue
Corey B. Puryear
author_sort Jay Pathmanathan
collection DOAJ
description Sleep is a stereotyped and well-preserved series of neurophysiological states that are essential for overall health and brain functioning. Emerging research suggests that sleep disturbances are not only associated with but also causally contribute to neurodegenerative disease onset and progression. This mini-review examines some of the current knowledge and evidence for relationships between sleep abnormalities and Alzheimer’s disease within context of possible uses and limitations of sleep biomarkers for evaluation of Alzheimer’s disease. Understanding these relationships could lead to readily accessible and easily quantifiable biomarkers of Alzheimer’s dementia.
format Article
id doaj-art-3f4093b169dc4087931faf26c0b95bc3
institution Kabale University
issn 1662-453X
language English
publishDate 2025-02-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Neuroscience
spelling doaj-art-3f4093b169dc4087931faf26c0b95bc32025-02-05T07:32:33ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-02-011910.3389/fnins.2025.14287331428733The role of sleep in Alzheimer’s disease: a mini reviewJay PathmanathanM. Brandon WestoverSudhir SivakumaranJacob DonoghueCorey B. PuryearSleep is a stereotyped and well-preserved series of neurophysiological states that are essential for overall health and brain functioning. Emerging research suggests that sleep disturbances are not only associated with but also causally contribute to neurodegenerative disease onset and progression. This mini-review examines some of the current knowledge and evidence for relationships between sleep abnormalities and Alzheimer’s disease within context of possible uses and limitations of sleep biomarkers for evaluation of Alzheimer’s disease. Understanding these relationships could lead to readily accessible and easily quantifiable biomarkers of Alzheimer’s dementia.https://www.frontiersin.org/articles/10.3389/fnins.2025.1428733/fullsleepAlzheimer’s diseasereviewsleep monitoringneurodegenerative disease
spellingShingle Jay Pathmanathan
M. Brandon Westover
Sudhir Sivakumaran
Jacob Donoghue
Corey B. Puryear
The role of sleep in Alzheimer’s disease: a mini review
Frontiers in Neuroscience
sleep
Alzheimer’s disease
review
sleep monitoring
neurodegenerative disease
title The role of sleep in Alzheimer’s disease: a mini review
title_full The role of sleep in Alzheimer’s disease: a mini review
title_fullStr The role of sleep in Alzheimer’s disease: a mini review
title_full_unstemmed The role of sleep in Alzheimer’s disease: a mini review
title_short The role of sleep in Alzheimer’s disease: a mini review
title_sort role of sleep in alzheimer s disease a mini review
topic sleep
Alzheimer’s disease
review
sleep monitoring
neurodegenerative disease
url https://www.frontiersin.org/articles/10.3389/fnins.2025.1428733/full
work_keys_str_mv AT jaypathmanathan theroleofsleepinalzheimersdiseaseaminireview
AT mbrandonwestover theroleofsleepinalzheimersdiseaseaminireview
AT sudhirsivakumaran theroleofsleepinalzheimersdiseaseaminireview
AT jacobdonoghue theroleofsleepinalzheimersdiseaseaminireview
AT coreybpuryear theroleofsleepinalzheimersdiseaseaminireview
AT jaypathmanathan roleofsleepinalzheimersdiseaseaminireview
AT mbrandonwestover roleofsleepinalzheimersdiseaseaminireview
AT sudhirsivakumaran roleofsleepinalzheimersdiseaseaminireview
AT jacobdonoghue roleofsleepinalzheimersdiseaseaminireview
AT coreybpuryear roleofsleepinalzheimersdiseaseaminireview